Protein
Vacuolar protein sorting-associated protein atg6
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Function
Required for cytoplasm to vacuole transport (Cvt), autophagy, nucleophagy, and mitophagy, as a part of the autophagy-specific vps34 PI3-kinase complex I. This complex is essential to recruit the atg8-phosphatidylinositol conjugate and the atg12-atg5 conjugate to the preautophagosomal structure. Also involved in endosome-to-Golgi retrograde transport as part of the vps34 PI3-kinase complex II (By similarity). Plays a role in meiosis and sporulation.
Similarity
Belongs to the beclin family.
Sequence
MQYLCQRCHSLINFKDVYDDDLLKLKNLPKSRFVQASSLTEMNESGESDDQMNSSSEDYPAQRLQLYKKTISEGDYNFDNVPPPELRTPTLDSFVVLPAAKDGYEEEKNSPEEVNDLFSWKIEIYNRIFDLLSSKTKVDHPLCVECAELLTEEMSKTLRALKEEKKMYFNYDNFLSSQTVHEENTAALDSEIDELMKQINEKEEKIEEISDETDKLQKLLRELDEEKEKVYAEEQEFYNNLNQFQIKKLSLERQYDCANLEFEHNSRKLEKLQKMNVFSDIFYISHYSEPNGEGSIATINGLRLGRLPSQKVNWAEINAAWGMTVLLLDVLTEKLDFHSSSYQLKPFGSQSFIIRFDRDPNGNQVKPTKLDLFSSGELKIFMNRRFDQGMVAFLDYLHQFGDFCAAKTPSAVLPYAIENDRIGGKCIRLAFNQDENWTRALKFVLTDIKFLEAYVSSQDKQSNF