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ATE1

Gene
ATE1
Protein
Arginyl-tRNA--protein transferase 1
Organism
Arabidopsis thaliana
Length
632 amino acids
Function
Involved in the post-translational conjugation of arginine to the N-terminal aspartate or glutamate of a protein. This arginylation is required for degradation of the protein via the ubiquitin pathway. Component of the N-end rule pathway with ATE2 and PRT6 (PubMed:19255443, PubMed:19620738, PubMed:22020282). The N-end rule pathway regulates seed after-ripening, seedling sugar sensitivity, seedling lipid breakdown, and abscisic acid (ABA) sensitivity of germination (PubMed:19255443). The end-rule pathway regulates various aspects of leaf and shoot development (PubMed:19620738). Involved in the oxygen-dependent N-arginylation of RAP2-12, an activator of hypoxic gene expression. This N-terminal modification leads to ubiquitination by PRT6 and subsequent degradation of RAP2-12 under aerobic conditions (PubMed:22020282). Has an important role in the progression of leaf senescence (PubMed:12366806). Involved in disease resistance (PubMed:27173012). The end-rule pathway plays a role in regulating the timing and amplitude of the immune response following infection with the bacterial pathogen Pseudomonas syringae pv tomato (PubMed:27173012). Regulates the biosynthesis of plant-defense metabolites such as glucosinolates, and the biosynthesis and response to the phytohormone jasmonate (JA), which plays a key role in plant immunity (PubMed:27173012).
Similarity
Belongs to the R-transferase family.
Mass
71.541 kDa
Sequence
MSLKNDASSSHDGGSNRESVIDDHGRRKSTCGYCKSPARSSISHGLSAQTLTVYDYQALIDRGWRRSGTYLYKHEMDKTCCPPYTIRLKASDFVPTKEQQRVSRRLERFLDGKLDVQPREQRGASSSGDVSDTRRKTLGAAKSEENKKVEAVMDDLSKNIDQAVQLCIRSGEFPSNMQIPKASVKKVFCARRKKLAEGTEQILYTSNIAFPIAAAIKRIQTSEKEGINSAEGNRLSPETISEMLLSAMHKVGETPDVSIKVCKGHINFLSSAKDSFSDRDVVPNGNISRGANSLDGSETLHAKKDSENHQARKRKLEIHLKRSSFDPEEHELYKRYQLKVHNDKPGHVVESSYRRFLVDSPLIDVQPSGDEKVPPCGFGSFHQQYRIDGRLIAVGVVDILPKCLSSVYLFWDPDYAFLSLGKYSAIQEINWVIENQARCPSLQYYYLGYYIHSCSKMRYKAAYRPSELLCPLRFQWVPFEVARPMLDKKPYVILSDIAISHNQCSLLAGASETLVEPAASEHEDMEQGETNDNFMGCSDEDEDEDEDDDDDDDDDEEMYETESEDSHIESDPGSKDNDINNILIGLYGSQYRYKEMRQIITPVGRKQLEPMLQSYRKVVGAELSERMVYEIN

Gene
ate1
Protein
Arginyl-tRNA--protein transferase 1
Organism
Dictyostelium discoideum
Length
629 amino acids
Function
Involved in the post-translational conjugation of arginine to the N-terminal aspartate or glutamate of a protein. This arginylation is required for degradation of the protein via the ubiquitin pathway. Does not arginylate cysteine residues (By similarity).
Similarity
Belongs to the R-transferase family.
Mass
73.82 kDa
Sequence
MERFLMQSSLSTSSLIYPHGSYDSSCNYCDAGEDKKGRICYGMVADQLTCEDYQLLIDQGWRRSGTFLYKPNNSDKKTCCPQYTIRLDTSSFKPSKDNKSTIKKFNNYILNNIIKEKDSSTTSTTKDIINTTQIKSNTKNNNNKTNDENIIKLNNDIIEIILNNEFINKFNEQDKKILKENLKIKINSNKMIKETGSYSLSFGIFNKYRSELNQHSITIDQIINFTILEFNKTINNSDYQFNLEKGQNNHINFKMINSSQILNDSTKTKTLNIQNNSNKNSTTTATTATTTTTTTNEPKHKFEISIHKPKCTDEVFSLYCKYQKIIHKEDDEKTKSGFKRFLVDSPLIPIIHPDESYDDYVYDGKDDDDDDDDKDEKEDDEDEDQEDDEDEDDGNNEDEKKITKENKEKEIKNHIYKIGKKSKTLKTRKFGEIKTPKPGYGSFHQYYRLDGKLVGVGVIDILPECLSSVYFFYDPDFNFLSLGKYSALNEIEWVQKVSQSIPQLKYYYMGYYIHSCQKMKYKANYQPSQLLCLETFKWVEFKKAISFLQPDKKYSRFYFDENENNNNEKLTYFEKEPELLERVKFRQKNFTFHFSDVSVRFQNLLKDQVIDYINHVGPELTKELIFYFK

Gene
ATE1
Protein
Arginyl-tRNA--protein transferase 1
Organism
Homo sapiens
Length
518 amino acids
Function
Involved in the post-translational conjugation of arginine to the N-terminal aspartate or glutamate of a protein. This arginylation is required for degradation of the protein via the ubiquitin pathway. Does not arginylate cysteine residues (By similarity).
Similarity
Belongs to the R-transferase family.
Mass
59.09 kDa
Sequence
MAFWAGGSPSVVDYFPSEDFYRCGYCKNESGSRSNGMWAHSMTVQDYQDLIDRGWRRSGKYVYKPVMNQTCCPQYTIRCRPLQFQPSKSHKKVLKKMLKFLAKGEVPKGSCEDEPMDSTMDDAVAGDFALINKLDIQCDLKTLSDDIKESLESEGKNSKKEEPQELLQSQDFVGEKLGSGEPSHSVKVHTVPKPGKGADLSKPPCRKAKEIRKERKRLKLMQQNPAGELEGFQAQGHPPSLFPPKAKSNQPKSLEDLIFESLPENASHKLEVRVVRSSPPSSQFKATLLESYQVYKRYQMVIHKNPPDTPTESQFTRFLCSSPLEAETPPNGPDCGYGSFHQQYWLDGKIIAVGVIDILPNCVSSVYLYYDPDYSFLSLGVYSALREIAFTRQLHEKTSQLSYYYMGFYIHSCPKMKYKGQYRPSDLLCPETYVWVPIEQCLPSLENSKYCRFNQDPEAVDEDRSTEPDRLQVFHKRAIMPYGVYKKQQKDPSEEAAVLQYASLVGQKCSERMLLFRN

Gene
ATE1
Protein
Arginyl-tRNA--protein transferase 1
Organism
Macaca fascicularis
Length
518 amino acids
Function
Involved in the post-translational conjugation of arginine to the N-terminal aspartate or glutamate of a protein. This arginylation is required for degradation of the protein via the ubiquitin pathway. Does not arginylate cysteine residues (By similarity).
Similarity
Belongs to the R-transferase family.
Mass
59.014 kDa
Sequence
MAFWAGGSPSVVDYFPSEDFYRCGYCKNESGSRSNGMWAHSMTVQDYQDLIDRGWRRSGKYVYKPVMNQTCCPQYTIRCRPLQFQPSKSHKKVLKKMLKFLAKGEVPKGSCEDEPMDSTMDDAVAGDFALINKLDIQCDLKTLSDDVKESLQSEGKNSKKEEPHELLQSQDSVGEKLGSGEPSHSVKVHTVPKPGKGADLSKPPCRKAKEIRKERKRLKLMQQNPAGELEGFQAQGHPPSLFPPKAKSNQPKSLEDLIFESLPENASHKLEVRLVPASFEDPEFKSSFSQSFSLYVKYQVAIHQDLPDECGKTEFTRFLCSSPLEAETPPNGPDCGYGSFHQQYWLDGKIIAVGVIDILPNYVSSVYLYYDPDYSFLSLGVYSALREIAFTRQLHEKTSQLSYYYMGFYIHSCPKMKYKGQYRPSDLLCPETYVWVPIEQCLPSLENSKYCRFNQDPEAVDEDRSTEPDRLQVFHKRAIMPYGVYKKQQKDPSEEAAVLQYASLVGQKCSERMLLFRN

Gene
Ate1
Protein
Arginyl-tRNA--protein transferase 1
Organism
Mus musculus
Length
516 amino acids
Function
Involved in the post-translational conjugation of arginine to the N-terminal aspartate or glutamate of a protein. This arginylation is required for degradation of the protein via the ubiquitin pathway. Does not arginylate cysteine residues.
Similarity
Belongs to the R-transferase family.
Mass
59.146 kDa
Sequence
MASWSAPSPSLVEYFEGQTSFQCGYCKNKLGSRSYGMWAHSMTVQDYQDLIDRGWRRSGKYVYKPVMDQTCCPQYTIRCHPLQFQPSKSHKKVLKKMLKFLAKGEISKGNCEDEPMDSTVEDAVDGDFALINKLDIKCDLKTLSDLKGSIESEEKEKEKSIKKEGSKEFIHPQSIEEKLGSGEPSHPIKVHIGPKPGKGADLSKPPCRKAREMRKERQRLKRMQQASAAASEAQGQPVCLLPKAKSNQPKSLEDLIFQSLPENASHKLEVRVVRSSPPSPQFRATFQESYQVYKRYQMVVHKDPPDKPTVSQFTRFLCSSPLEAEHPADGPECGYGSFHQQYWLDGKIIAVGVLDILPYCVSSVYLYYDPDYSFLSLGVYSALREIAFTRQLHEKTSQLSYYYMGFYIHSCPKMRYKGQYRPSDLLCPETYVWVPIEQCLPSLDNSKYCRFNQDPEAEDEGRSKELDRLRVFHRRSAMPYGVYKNHQEDPSEEAGVLEYANLVGQKCSERMLLFRH

Gene
ATE1
Protein
Arginyl-tRNA--protein transferase 1
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Length
503 amino acids
Function
Involved in the post-translational conjugation of arginine to the N-terminal aspartate or glutamate of a protein. This arginylation is required for degradation of the protein via the ubiquitin pathway. Does not arginylate cysteine residues (By similarity).
Similarity
Belongs to the R-transferase family.
Mass
57.93 kDa
Sequence
MSDRFVIWAPSMHNEPAAKCGYCHGNKGGNMDQLFALDSWAHRYMNKMDVVKIENCTIGSFVEHMDVATYDRMCNMGFRRSGKFLYKVDPLRNCCRLYTIRTAPQELNMTKELKKCISRFATRITSEDYCPAAVASSDFVGKIVNAEMNSKTFYTRFEPALYSEEKYHLFVKYQEKVHQDYNNSPKSFKRFLCDTPFGPEAVLGTQESWEQLNNWQRMKPGEKLKHMGPVHECYYYEGKLIAITVSDILPSGISSVYFIWDPDYSKWSLGKLSALRDLAIIQRTNLQYYYLGYYIEDCPKMNYKANYGAEVLDVCHSKYIPLKPIQDMISRGKLFVIGEEETKVTKELYLVDSETGRGEGFPTDNVVKYKNIAEEIYGVGGCAFKSANESALELKELYGIPYEEEDLDTIYHLKEHNGHAPNGIPNVVPGLLPLWELLDIMQSGKITDLEGRLFLFEIETEGIRPLINFYSEPPNVKKRICDVIRLFGFETCMKAVILYSEQM

Gene
Ate1
Protein
Arginyl-tRNA--protein transferase 1
Organism
Drosophila melanogaster
Length
484 amino acids
Function
Involved in the post-translational conjugation of arginine to the N-terminal aspartate or glutamate of a protein. This arginylation is required for degradation of the protein via the ubiquitin pathway. Does not arginylate cysteine residues (By similarity).
Similarity
Belongs to the R-transferase family.
Mass
55.317 kDa
Sequence
MSLSIVSYYGSQQSKCGYCAGANCSLSHGMHAYQLDCRDYQDLIDRGWRRCGYYCYKLRNQETCCPCYTIKCNGLEFKLSKSNKRILRRINRFLRDGKRESKPEAGDGDGEADADYAIVAPEVTASEPQPQLPDKSPPVINVEQVASLATAQRKPTKQATAAAVEAPTLGSNKSSLLSSSAAAPISNKPCKKAKQMRLDRRLAKLGDSASYSTKSLTQEKTLRDFLNTDSETNKHRLKLRLIHVYDDEFRRTLPQSFALYKKYQISIHNDPPKDQDAYKEHLQATPLQNEKPWDGPEMGYGSFHQQYWLDDKLIAVGVIDILPGCVSSVYFFYDPDYSFLSLGTYGSLREIELVQSLAEKVPSLKYYYMGFYIHSCPKMRYKGKLSPSYLLCPETYEWLPLTDVIRAKLDEHKYQRLNEDPAARDVNEFLMEHLDEVKLLLGGRTRTDYKHFRQLRGTVSDDDIIIEYSKLVGKECARRMLYVK