ASXL2

Putative Polycomb group protein ASXL2

1435 amino acids

Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via methylation of histones, rendering chromatin heritably changed in its expressibility (By similarity). Involved in transcriptional regulation mediated by ligand-bound nuclear hormone receptors, such as peroxisome proliferator-activated receptor gamma (PPARG). Acts as coactivator for PPARG and enhances its adipocyte differentiation-inducing activity; the function seems to involve differential recruitment of acetylated and methylated histone H3.

Belongs to the Asx family.

153.82 kDa

MREKGRRKKGRTWAEAAKTVLEKYPNTPMSHKEILQVIQREGLKEIRSGTSPLACLNAMLHTNSRGEEGIFYKVPGRMGVYTLKKDVPDGVKELSEGSEESSDGQSDSQSSENSSSSSDGGSNKEGKKSRWKRKVSSSSPQSGCPSPTIPAGKVISPSQKHSKKALKQALKQQQQKKQQQQCRPSISISSNQHLSLKTVKAASDSVPAKPATWEGKQSDGQTGSPQNSNSSFSSSVKVENTLLGLGKKSFQRSERLHTRQMKRTKCADIDVETPDSILVNTNLRALINKHTFSVLPGDCQQRLLLLLPEVDRQVGPDGLMKLNGSALNNEFFTSAAQGWKERLSEGEFTPEMQVRIRQEIEKEKKVEPWKEQFFESYYGQSSGLSLEDSKKLTASPSDPKVKKTPAEQPKSMPVSEASLIRIVPVVSQSECKEEALQMSSPGRKEECESQGEVQPNFSTSSEPLLSSALNTHELSSILPIKCPKDEDLLEQKPVTSAEQESEKNHLTTASNYNKSESQESLVTSPSKPKSPGVEKPIVKPTAGAGPQETNMKEPLATLVDQSPESLKRKSSLTQEEAPVSWEKRPRVTENRQHQQPFQVSPQPFLNRGDRIQVRKVPPLKIPVSRISPMPFHPSQVSPRARFPVSITSPNRTGARTLADIKAKAQLVKAQRAAAAAAAAAAAAASVGGTIPGPGPGGGQGPGEGGEGQTARGGSPGSDRVSETGKGPTLELAGTGSRGGTRELLPCGPETQPQSETKTTPSQAQPHSVSGAQLQQTPPVPPTPAVSGACTSVPSPAHIEKLDNEKLNPTRATATVASVSHPQGPSSCRQEKAPSPTGPALISGASPVHCAADGTVELKAGPSKNIPNPSASSKTDASVPVAVTPSPLTSLLTTATLEKLPVPQVSATTAPAGSAPPSSTLPAASSLKTPGTSLNMNGPTLRPTSSIPANNPLVTQLLQGKDVPMEQILPKPLTKVEMKTVPLTAKEERGMGALIATNTTENSTREEVNERQSHPATQQQLGKTLQSKQLPQVPRPLQLFSAKELRDSSIDTHQYHEGLSKATQDQILQTLIQRVRRQNLLSVVPPSQFNFAHSGFQLEDISTSQRFMLGFAGRRTSKPAMAGHYLLNISTYGRGSESFRRTHSVNPEDRFCLSSPTEALKMGYTDCKNATGESSSSKEDDTDEESTGDEQESVTVKEEPQVSQSAGKGDTSSGPHSRETLSTSDCLASKNVKAEIPLNEQTTLSKENYLFTRGQTFDEKTLARDLIQAAQKQMAHAVRGKAIRSSPELFSSTVLPLPADSPTHQPLLLPPLQTPKLYGSPTQIGPSYRGMINVSTSSDMDHNSAVPGSQVSSNVGDVMSFSVTVTTIPASQAMNPSSHGQTIPVQAFSEENSIEGTPSKCYCRLKAMIMCKGCGAFCHDDCIGPSKLCVSCLVVR

ASXL2

Putative Polycomb group protein ASXL2

1412 amino acids

Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via methylation of histones, rendering chromatin heritably changed in its expressibility. heritably changed in its expressibility. Involved in transcriptional regulation mediated by ligand-bound nuclear hormone receptors (By similarity).

Belongs to the Asx family.

148.669 kDa

MREKGRRKKGRTWAEAARTVLEKYPNTPMSHKEILQVIQKEGLKEIRSGTSPLACLNAMLHTNSRGEEGIFYKVPGRMGVYTLKKDVPDGLKELSDGSEESSDAQSDSQSSENSSSSSSSDGCTNKDGRKSRWKRKVSSRLSQTSSPQTSCQSPSIQTGKVISSSQKHSKKALKQALKQQQQKQQQQQCRAGMPVSSNQHTLLKAVKAASASTPTKPAWIGKQSDGHSNSSQNSTFSSSASVKLDNSLPGLGKKPFQRSDRLHARQLKRTKCAEIDVETPDSILVNTNLRALINKHTFSVLPTECQQRLLLLLPEVDRQVGADGLMKLSGSALNNEFFTSAAQGWKERLSEGEFTPEMQLRIRQEIEKEKKVELWKEHFFESYYGQSSGLSPEESERLTANTSADDGEAEKPAAEQPKCMQVKEEITSPSESKAQVVQEAPAVKKGEERRVEERREEMQPKAAKPAEASVSPAGCAVKPSNPQIQERIQGEPIQENPQPAVSQKLEEERKHTASKEVKEAVRAPVLAPSKPKSPEAGEAAAKVTSPVVVPPTPEKKPPVNEEMEVSVEGHKRKSESSEEALTTPGKKPRIAEKCQQQQPAFRSQTQSFPAAGPPVPRVPPLKIPVSRISPMPFPAGQVSPRVRFPASLISPARTGARTLADIKAKAQQVRAQRAAAAAAAAAASSGGAVPGPGPGGGPAGGGGTGNAATSGAGETGTRGNALELAGTGSGGSSRRFLPRCPGTHSPMETQEQPATPSLSRAQLQQTSVLQSRSAAGNTGTNCSSPAVSAIEQISGIKQSPPNVAINQVSGSSCAGGCDKQEKAPSAPAGLGQACGASTVRDGTTCVTVSSADSNANITRVAPAALGGTSSDVPKGTSPSPLMPSLTPTSSEAQAGGAVVSAPSAPCSNTLSAAPSLKTHPSSSGALPKANSSIPANNPLVTQLLQGKSVPLEQILPKPLTKAEMKTVPLASNEEKGAAVPGVAGSGAGAEGGERQSALSPQQLGKIFCQSRPLPHIPRTFVLPAGKEPGADQHPEALSKTTQEQILQTLIKRVQRQNLLPVLQPSQVNVAHSGFQLENSSTSQRFVLGFMGRRTSKPAMSGHYLLNISTYGRGSESLRRGFSLNPETRSCLNSPAGGPKAECGECEEMPDHGSSSEEEDADNESTGDEHEHVSVKEEPQASQVAAPCEKEQVSHGANSSDYGILAKKGVKTEAAVSQQAAGSRENSQALDGTALARDFIQAAQEQTVHAVKGKTHSSPELFSSSTPSSDSAQLQLPQLSHPHPPKLGGDAAAAQLIGPSYSGTINVSTSPDVNQGSLMSGLSECNQLSSSMGNVMSFSVTVTTIPTSQAMNSGNHSQTIPVQAFAEDSSMEDSPSKCYCRLKAMIMCKGCGAFCHDDCIGPSKLCVSCLVVR

Asxl2

Putative Polycomb group protein ASXL2

1370 amino acids

Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via methylation of histones, rendering chromatin heritably changed in its expressibility. Involved in transcriptional regulation mediated by ligand-bound nuclear hormone receptors, such as peroxisome proliferator-activated receptor gamma (PPARG). Acts as coactivator for PPARG and enhances its adipocyte differentiation-inducing activity; the function seems to involve differential recruitment of acetylated and methylated histone H3 (By similarity).

Belongs to the Asx family.

147.107 kDa

MREKGRRKKGRTWAEAAKTVLEKYPNTPMSHKEILQVIQREGLKEIRSGTSPLACLNAMLHTNSRGEEGIFYKVPGRMGVYTLKKDVPDGVKELSECSEESSDGQSDSHSSDNSSSSDGGSNKEGRKSRWKRKVSSRLSHPPSPPSGCPSPTIPASKVISPSQKHSKKALKQALKQQQQKKKQQQCRPSMSISNQHLSLKTVKAASDSVPAKPGQMKRTKCADIDVETPDSILVNTNLRALINKHTFSVLPGDCQQRLLLLLPEVDRQVGPDGLMKLNGSALNNEFFTSAAQGWKERLSEGEFTPEMQVRIRQEIEKEKKVELWKEQFFENYYGQSSGLSLEDSQKLTASSSDPKAKKTPAEQPKSILPSEASPVRIVPVVPQSECKEEAVQIPSPSQKEENQDEARPDSKSPEPVLASASNTNELITMKPIKSPKDEGLLEQKPVACAEQESEKENHVTTTSRNNKSENQEALAISPSKSKNAGLQKPIIKPVAEASPLNPDMKMPPATVTDQIQESLKRKSSLTDEEATSSWEKRPRITENRQHQQPFQVSPQPFLNRGDRVQVRKVPPLKIPVSRISPMLFSTSQVSPRARFPISITSPYRTGARTLADIKAKAQLVEAQKAAAAAAAAAAAAASVGGTIPGPGPGGGQSPREGGERKIAGGGSAGSDPVSTNGKGPTLELAGTGSRGGTRELLPCGPQPETNMPGQAQPPGISGAQLQQTSSVPTGLASSGACTSVPLPAHIEISNSEKPNLHKATATAASPCHLQDPRSCRLEKALSPTGPPLISGASTVYFVADGTVEPKAGSNKNAPKPSALAKTTAPAPLDMTSSPVTTASLEKLPVPQISGTATSTGSAPSSSTLPAASSLKTPGTSANMNGPISRTSSSIPANNPLVTQLLQGKDVPLEQILPKPLTKIEMKTVPLTTKEEKGIGIFPGISVMESSSREEVNGRQAHLAIPQLGKPLQSKQLSQVPRPVFTAKDRKDPCIDTHQYREGLSKTTQDQLFQTLIQRAQRQSVLSFVPPSQFNFAHSGFHLEDISTSQKFMLGFAGRRTSKPAMAGHYLLNISTYGRGTENIKRTHSVNPDDRFCLSSPTEALRMGHADYKNTTGEISSKEDESDEDRVGDEQEPISVKEEPWASQSSGRHPHHGEASSTNDCLASKNGKTEAPVSEQTTLGQENYIFSRGQASDEKSLPRDFIPAAHKQMTHAVRGKTVCSSPELFNSTALSLPADSPTHQPLLLPPLQTPKLYGSPTQIGPSYRGMINVSTSSDMDHNSAIPGSQVSSNVGDVMSFSVTVTTIPASQAMNPSSHGQTIPVQTFPDDNSIEDTPSKCYCRLKAMIMCKGCGAFCHDDCIGPSKLCVSCLVVR