About Products Protein Database Contact

ASPN

Gene
ASPN
Protein
Asporin
Organism
Homo sapiens
Length
380 amino acids
Function
Negatively regulates periodontal ligament (PDL) differentiation and mineralization to ensure that the PDL is not ossified and to maintain homeostasis of the tooth-supporting system. Inhibits BMP2-induced cytodifferentiation of PDL cells by preventing its binding to BMPR1B/BMP type-1B receptor, resulting in inhibition of BMP-dependent activation of SMAD proteins (By similarity). Critical regulator of TGF-beta in articular cartilage and plays an essential role in cartilage homeostasis and osteoarthritis (OA) pathogenesis. Negatively regulates chondrogenesis in the articular cartilage by blocking the TGF-beta/receptor interaction on the cell surface and inhibiting the canonical TGF-beta/Smad signal. Binds calcium and plays a role in osteoblast-driven collagen biomineralization activity.
Similarity
Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.
Mass
43.417 kDa
Sequence
MKEYVLLLFLALCSAKPFFSPSHIALKNMMLKDMEDTDDDDDDDDDDDDDDEDNSLFPTREPRSHFFPFDLFPMCPFGCQCYSRVVHCSDLGLTSVPTNIPFDTRMLDLQNNKIKEIKENDFKGLTSLYGLILNNNKLTKIHPKAFLTTKKLRRLYLSHNQLSEIPLNLPKSLAELRIHENKVKKIQKDTFKGMNALHVLEMSANPLDNNGIEPGAFEGVTVFHIRIAEAKLTSVPKGLPPTLLELHLDYNKISTVELEDFKRYKELQRLGLGNNKITDIENGSLANIPRVREIHLENNKLKKIPSGLPELKYLQIIFLHSNSIARVGVNDFCPTVPKMKKSLYSAISLFNNPVKYWEMQPATFRCVLSRMSVQLGNFGM

Gene
Aspn
Protein
Asporin
Organism
Mus musculus
Length
373 amino acids
Function
Binds calcium and plays a role in osteoblast-driven collagen biomineralization activity (By similarity). Critical regulator of TGF-beta in articular cartilage and plays an essential role in cartilage homeostasis and osteoarthritis (OA) pathogenesis. Negatively regulates chondrogenesis in the articular cartilage by blocking the TGF-beta/receptor interaction on the cell surface and inhibiting the canonical TGF-beta/Smad signal. Negatively regulates periodontal ligament (PDL) differentiation and mineralization to ensure that the PDL is not ossified and to maintain homeostasis of the tooth-supporting system. Inhibits BMP2-induced cytodifferentiation of PDL cells by preventing its binding to BMPR1B/BMP type-1B receptor, resulting in inhibition of BMP-dependent activation of SMAD proteins. Inhibits the interaction between TGFB1 and TGF-beta receptor type II in the presence of heparin/heparan sulfate in vitro.
Similarity
Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.
Mass
42.573 kDa
Sequence
MKEYVMLLLLAVCSAKPFFSPSHTALKNMMLKDMEDTDDDDNDDDDNSLFPTKEPVNPFFPFDLFPTCPFGCQCYSRVVHCSDLGLTSVPNNIPFDTRMVDLQNNKIKEIKENDFKGLTSLYALILNNNKLTKIHPKTFLTTKKLRRLYLSHNQLSEIPLNLPKSLAELRIHDNKVKKIQKDTFKGMNALHVLEMSANPLENNGIEPGAFEGVTVFHIRIAEAKLTSIPKGLPPTLLELHLDFNKISTVELEDLKRYRELQRLGLGNNRITDIENGTFANIPRVREIHLEHNKLKKIPSGLQELKYLQIIFLHYNSIAKVGVNDFCPTVPKMKKSLYSAISLFNNPMKYWEIQPATFRCVLGRMSVQLGNVGK

Gene
ASPN
Protein
Asporin
Organism
Bos taurus
Length
370 amino acids
Similarity
Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.
Mass
42.119 kDa
Sequence
MKVYVLLVFLTLCSAKPLFHPSYLTLKNLMLKDMEDEGDSDADNSLFPTREPINPFFPFDLFSTCPFGCQCYSRVVHCSDLGLSSVPSNIPFDTRMVDLQNNKIKEIKENDFKGLTSLYALILNNNKLTKIHPKAFLTTKKLRRLYLSHNQLSEIPLNLPKSLAELRIHDNKVKKIQKATFKGMNALHVLEMSANPLDNNGIEPGAFEGVTVFHIRIAEAKLTSIPKELPSTLLELHLDYNKISVVELEDFKRYKDLQRLGLGNNRITDIENGSLANIPRVREIHLENNKLKKVPSGLQELKYLQIIFLHSNSITKVGVNDFCPTVPKMKKSLYSAISLSNNPVKYWEVQPATFRCVLSRMSVQLGNFRK