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ASIP

Gene
ASIP
Protein
Agouti-signaling protein
Organism
Felis catus
Length
135 amino acids
Function
Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment) (By similarity).
Mass
14.948 kDa
Sequence
MNILRLLLATLLVCLCLLTAYSHLAPEEKPRDDRNLRSNSSMNMLDLSSVSIVALNKKSKKISRKEAEKKRSSKKKASMKNVAQPRRPRPPPPAPCVATRDSCKPPAPACCDPCASCQCRFFRSSCSCRVLNPTC

Gene
ASIP
Protein
Agouti-signaling protein
Organism
Bos taurus
Length
133 amino acids
Function
Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment) (By similarity).
Mass
14.841 kDa
Sequence
MDVSRLLLATLLVCLCFLTAYSHLAPEEKPRDERNLKNNSSMNLLDFPSVSIVALNKKSKKISRNEAEKKKRPSKRKAPMKNVARTRPPPPTPCVATRDSCKPPAPACCDPCAFCQCRFFRSACSCRVLNPTC

Gene
ASIP
Protein
Agouti-signaling protein
Organism
Equus caballus
Length
133 amino acids
Function
Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment) (By similarity).
Mass
14.78 kDa
Sequence
MDVIHLFLATLLVSLCFLTAYSHLSPEEKPKDDRSLRNNSSMNLLDSPSVSIMALNKKSKKISRKEAEKKKRSSKKKASMTKVARPRLLQPAPCVATRDSCKPPAPACCDPCASCQCRFFRSACSCRVLTRTC

Gene
ASIP
Protein
Agouti-signaling protein
Organism
Macaca sylvanus
Length
132 amino acids
Function
Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment) (By similarity).
Mass
14.673 kDa
Sequence
MDVTRLLLATLLVFLCFFTAYSHLPPEEKLRDDRSLRSNSSVNLLDFPSVSIVALNKKSKQISRKEAEKKRSSKKEASMKKVARPRTPLSAPCVATRDSCKPPAPACCDPCASCQCRFFRSACSCRVLSLNC

Gene
ASIP
Protein
Agouti-signaling protein
Organism
Pan paniscus
Length
132 amino acids
Function
Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment) (By similarity).
Mass
14.593 kDa
Sequence
MDVTRLLLATLLVFLCFFTANSHLPPEEKLRDDRSLRSNSSVNLLDFPSVSIVALNKKSKQIGRKEAEKKRSSKKEASMKKVARPRTPLSAPCVATRNSCKPPAPACCDPCASCQCRFFRSACSCRVLSLNC

Gene
ASIP
Protein
Agouti-signaling protein
Organism
Pan troglodytes
Length
132 amino acids
Function
Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment) (By similarity).
Mass
14.593 kDa
Sequence
MDVTRLLLATLLVFLCFFTANSHLPPEEKLRDDRSLRSNSSVNLLDFPSVSIVALNKKSKQIGRKEAEKKRSSKKEASMKKVARPRTPLSAPCVATRNSCKPPAPACCDPCASCQCRFFRSACSCRVLSLNC

Gene
ASIP
Protein
Agouti-signaling protein
Organism
Papio anubis
Length
132 amino acids
Function
Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment) (By similarity).
Mass
14.673 kDa
Sequence
MDVTRLLLATLLVFLCFFTAYSHLPPEEKLRDDRSLRSNSSVNLLDFPSVSIVALNKKSKQISRKEAEKKRSSKKEASMKKVARPRTPLSAPCVATRDSCKPPAPACCDPCASCQCRFFRSACSCRVLSLNC

Gene
ASIP
Protein
Agouti-signaling protein
Organism
Pongo pygmaeus
Length
132 amino acids
Function
Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment) (By similarity).
Mass
14.597 kDa
Sequence
MDVTRLLLATLLVFLCFFTADSHLPPEEKLRDDRSLRSNSSVNLLDFPSVSIVALNKKSKQISRKEAEKKRSSKKEASMKTVARPRTPLSAPCVATRNSCKPPAPACCDPCASCQCRFFRSACSCRVLSLNC

Gene
ASIP
Protein
Agouti-signaling protein
Organism
Semnopithecus entellus
Length
132 amino acids
Function
Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment) (By similarity).
Mass
14.79 kDa
Sequence
MDVTRLLLATLLVFLCFFTVYSHLPPEEKLRDDRSLRSNSSVNLLDFPSVSIVALNKKSKQISRKEAEKKRSSKKEASMKKVAQPRTPLSAPCVATRYSCKPPAPACCDPCASCQCRFFRSACSCRVLRLNC

Gene
ASIP
Protein
Agouti-signaling protein
Organism
Trachypithecus auratus
Length
132 amino acids
Function
Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment) (By similarity).
Mass
14.673 kDa
Sequence
MDVTRLLLATLLVFLCFFTVYSHLPPEEKLRDDRSLRSNSSVNLLDFPSVSIVALNKKSKQISRKEAEKKRSSKKEASMKKVAQPRTPLSAPCVATRDSCKPPAPACCDPCASCQCRFFRSACSCRVLSLNC

Gene
ASIP
Protein
Agouti-signaling protein
Organism
Trachypithecus cristatus
Length
132 amino acids
Function
Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment) (By similarity).
Mass
14.673 kDa
Sequence
MDVTRLLLATLLVFLCFFTVYSHLPPEEKLRDDRSLRSNSSVNLLDFPSVSIVALNKKSKQISRKEAEKKRSSKKEASMKKVAQPRTPLSAPCVATRDSCKPPAPACCDPCASCQCRFFRSACSCRVLSLNC

Gene
ASIP
Protein
Agouti-signaling protein
Organism
Trachypithecus francoisi
Length
132 amino acids
Function
Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment) (By similarity).
Mass
14.673 kDa
Sequence
MDVTRLLLATLLVFLCFFTVYSHLPPEEKLRDDRSLRSNSSVNLLDFPSVSIVALNKKSKQISRKEAEKKRSSKKEASMKKVAQPRTPLSAPCVATRDSCKPPAPACCDPCASCQCRFFRSACSCRVLSLNC

Gene
ASIP
Protein
Agouti-signaling protein
Organism
Trachypithecus obscurus
Length
132 amino acids
Function
Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment) (By similarity).
Mass
14.673 kDa
Sequence
MDVTRLLLATLLVFLCFFTVYSHLPPEEKLRDDRSLRSNSSVNLLDFPSVSIVALNKKSKQISRKEAEKKRSSKKEASMKKVAQPRTPLSAPCVATRDSCKPPAPACCDPCASCQCRFFRSACSCRVLSLNC

Gene
ASIP
Protein
Agouti-signaling protein
Organism
Callithrix geoffroyi
Length
132 amino acids
Function
Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment) (By similarity).
Mass
14.627 kDa
Sequence
MDVTRLLLATLLVFLCFFAAYSHLPPEEKLRDDRSLRSNSSVNLLDLPSVSIVALNKKSKKISRKEAEKKRSSKKEASKQKVARPRTPLSVPCVSTRGSCKPPAPACCHPCASCQCRFFRSACSCRVLNVNC

Gene
ASIP
Protein
Agouti-signaling protein
Organism
Callimico goeldii
Length
132 amino acids
Function
Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment) (By similarity).
Mass
14.627 kDa
Sequence
MDVTRLLLATLLVFLCFFAAYSHLPPEEKLRDDRSLRSNSSVNLLDLPSVSIVALNKKSKKISRKEAEKKRSSKKEASKQKVARPRTPLSVPCVSTRGSCKPPAPACCHPCASCQCRFFRSACSCRVLNVNC

Gene
ASIP
Protein
Agouti-signaling protein
Organism
Callithrix jacchus
Length
132 amino acids
Function
Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment) (By similarity).
Mass
14.627 kDa
Sequence
MDVTRLLLATLLVFLCFFAAYSHLPPEEKLRDDRSLRSNSSVNLLDLPSVSIVALNKKSKKISRKEAEKKRSSKKEASKQKVARPRTPLSVPCVSTRGSCKPPAPACCHPCASCQCRFFRSACSCRVLNVNC

Gene
ASIP
Protein
Agouti-signaling protein
Organism
Callithrix pygmaea
Length
132 amino acids
Function
Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment) (By similarity).
Mass
14.641 kDa
Sequence
MDVTRLVLATLLVFLCFFAAYSHLPPEEKLRDDRSLRSNSSVNLLDLPSVSIVALNKKSKKISRKEAEKRRSSKKEASKQKVARPRTPLSVPCVSTRGSCKPPAPACCHPCASCQCRFFRSACSCRVLNVNC

Gene
ASIP
Protein
Agouti-signaling protein
Organism
Cercopithecus mitis
Length
132 amino acids
Function
Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment) (By similarity).
Mass
14.691 kDa
Sequence
MDVTRLLLATLLVFLCFFTAYSHLPPEEKLRDDRSLRSNSSVNLLDFPSVSIVALNKKSKQMSRKEAEKKRSSKKEASMKKVARPRTPLSAPCVATRDSCKPPAPACCDPCASCQCRFFRSACSCRVLSLNC

Gene
ASIP
Protein
Agouti-signaling protein
Organism
Chlorocebus aethiops
Length
132 amino acids
Function
Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment) (By similarity).
Mass
14.673 kDa
Sequence
MDVTRLLLATLLVFLCFFTAYSHLPPEEKLRDDRSLRSNSSVNLLDFPSVSIVALNKKSKQISRKEAEKKRSSKKEASMKKVARPRTPLSAPCVATRDSCKPPAPACCDPCASCQCRFFRSACSCRVLSLNC

Gene
ASIP
Protein
Agouti-signaling protein
Organism
Colobus polykomos
Length
132 amino acids
Function
Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment) (By similarity).
Mass
14.71 kDa
Sequence
MDVTRLLLATLLVFLCFFTVYSHLPPEEKLRDDRSLRSNSSVNLLDFPSVSIVALNKKSKHISRKEAEKKRSSKKEASMKKVARPRTPLSAPCVATRDSCKPPAPACCDPCASCQCRFFRSACSCRVLSLNC

Gene
ASIP
Protein
Agouti-signaling protein
Organism
Erythrocebus patas
Length
132 amino acids
Function
Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment) (By similarity).
Mass
14.673 kDa
Sequence
MDVTRLLLATLLVFLCFFTAYSHLPPEEKLRDDRSLRSNSSVNLLDFPSVSIVALNKKSKQISRKEAEKKRSSKKEASMKKVARPRTPLSAPCVATRDSCKPPAPACCDPCASCQCRFFRSACSCRVLSLNC

Gene
ASIP
Protein
Agouti-signaling protein
Organism
Gorilla gorilla gorilla
Length
132 amino acids
Function
Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment) (By similarity).
Mass
14.593 kDa
Sequence
MDVTRLLLATLLVFLCFFTANSHLPPEEKLRDDRSLRSNSSVNLLDFPSVSIVALNKKSKQIGRKEAEKKRSSKKEASMKKVARPRTPLSAPCVATRNSCKPPAPACCDPCASCQCRFFRSACSCRVLSLNC

Gene
ASIP
Protein
Agouti-signaling protein
Organism
Homo sapiens
Length
132 amino acids
Function
Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment). In higher primates, agouti may affect the quality of hair pigmentation rather than its pattern of deposition. Could well play a role in neuroendocrine aspects of melanocortin action. May have some functional role in regulating the lipid metabolism with adipocytes.
Mass
14.515 kDa
Sequence
MDVTRLLLATLLVFLCFFTANSHLPPEEKLRDDRSLRSNSSVNLLDVPSVSIVALNKKSKQIGRKAAEKKRSSKKEASMKKVVRPRTPLSAPCVATRNSCKPPAPACCDPCASCQCRFFRSACSCRVLSLNC

Gene
ASIP
Protein
Agouti-signaling protein
Organism
Leontopithecus chrysomelas
Length
132 amino acids
Function
Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment) (By similarity).
Mass
14.524 kDa
Sequence
MDVTXLLLATLLVFLCCFAAYSHLPPEEKLRDDRSLRSNSSVNLLDLPSVSIVALNKKSKKISRKEAENKRSSKKEASKQKVARPRTPLSVPCVSTRGSCKPPAPACCHPCASCQCRFFRSACSCRVINVNC

Gene
ASIP
Protein
Agouti-signaling protein
Organism
Leontopithecus rosalia
Length
132 amino acids
Function
Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment) (By similarity).
Mass
14.524 kDa
Sequence
MDVTXLLLATLLVFLCCFAAYSHLPPEEKLRDDRSLRSNSSVNLLDLPSVSIVALNKKSKKISRKEAENKRSSKKEASKQKVARPRTPLSVPCVSTRGSCKPPAPACCHPCASCQCRFFRSACSCRVINVNC

Gene
ASIP
Protein
Agouti-signaling protein
Organism
Macaca arctoides
Length
132 amino acids
Function
Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment) (By similarity).
Mass
14.657 kDa
Sequence
MDVTRLLLATLLVFLCFFTAYSHPPPEEKLRDDRSLRSNSSVNLLDFPSVSIVALNKKSKQISRKEAEKKRSSKKEASMKKVARPRTPLSAPCVATRDSCKPPAPACCDPCASCQCRFFRSACSCRVLSLNC

Gene
ASIP
Protein
Agouti-signaling protein
Organism
Macaca assamensis
Length
132 amino acids
Function
Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment) (By similarity).
Mass
14.645 kDa
Sequence
MDVTRLLLATLLVFLCFFTAYSHPPPEEKLRDDRSLRSNSSVNLLDFPSVSIVALNKKSKQTSRKEAEKKRSSKKEASMKKVARPRTPLSAPCVATRDSCKPPAPACCDPCASCQCRFFRSACSCRVLSLNC

Gene
ASIP
Protein
Agouti-signaling protein
Organism
Macaca cyclopis
Length
132 amino acids
Function
Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment) (By similarity).
Mass
14.675 kDa
Sequence
MDVTRLLLATLLVFLCFFTAYSHPPPEEKLRDDRSLRSNSSVNLLDFPSVSIMALNKNSKQISRKEAEKKRSSKKEASMKKVARPRTPLSAPCVATRDSCKPPAPACCDPCASCQCRFFRSACSCRVLSLNC

Gene
ASIP
Protein
Agouti-signaling protein
Organism
Macaca fascicularis
Length
132 amino acids
Function
Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment) (By similarity).
Mass
14.692 kDa
Sequence
MDVTRLLLATLLVFLCFFTAYSHLPPEEKLRDDRSLRSNSSVNLLDFPSVSIMALNKNSKEISRKEAEKKRSSKKEASMKKVARPRTPLSAPCVATRDSCKPPAPACCDPCASCQCRFFRSACSCRVLSLNC

Gene
ASIP
Protein
Agouti-signaling protein
Organism
Macaca fuscata fuscata
Length
132 amino acids
Function
Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment) (By similarity).
Mass
14.692 kDa
Sequence
MDVTRLLLATLLVFLCFFTAYSHLPPEEKLRDDRSLRSNSSVNLLDFPSVSIMALNKNSKEISRKEAEKKRSSKKEASMKKVARPRTPLSAPCVATRDSCKPPAPACCDPCASCQCRFFRSACSCRVLSLNC

Gene
ASIP
Protein
Agouti-signaling protein
Organism
Macaca hecki
Length
132 amino acids
Function
Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment) (By similarity).
Mass
14.703 kDa
Sequence
MDVTRLLLATLLVFLCFFTAYSHPPPEEKLRDDRSLRSNSSVNLLDFPSVSIVALNKNSKQISRKEAEKKRSSKKEASMKKVARPRTPLSAPCVATRDSCKPPAPACCDPCAFCQCRFFRSACSCRVLSLNC

Gene
ASIP
Protein
Agouti-signaling protein
Organism
Macaca maura
Length
132 amino acids
Function
Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment) (By similarity).
Mass
14.643 kDa
Sequence
MDVTRLLLATLLVFLCFFTAYSHPPPEEKLRDDRSLRSNSSVNLLDFPSVSIVALNKNSKQISRKEAEKKRSSKKEASMKKVARPRTPLSAPCVATRDSCKPPAPACCDPCASCQCRFFRSACSCRVLSLNC

Gene
ASIP
Protein
Agouti-signaling protein
Organism
Macaca mulatta
Length
132 amino acids
Function
Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment) (By similarity).
Mass
14.692 kDa
Sequence
MDVTRLLLATLLVFLCFFTAYSHLPPEEKLRDDRSLRSNSSVNLLDFPSVSIMALNKNSKEISRKEAEKKRSSKKEASMKKVARPRTPLSAPCVATRDSCKPPAPACCDPCASCQCRFFRSACSCRVLSLNC

Gene
ASIP
Protein
Agouti-signaling protein
Organism
Macaca nemestrina
Length
132 amino acids
Function
Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment) (By similarity).
Mass
14.643 kDa
Sequence
MDVTRLLLATLLVFLCFFTAYSHPPPEEKLRDDRSLRSNSSVNLLDFPSVSIVALNKNSKQISRKEAEKKRSSKKEASMKKVARPRTPLSAPCVATRDSCKPPAPACCDPCASCQCRFFRSACSCRVLSLNC

Gene
ASIP
Protein
Agouti-signaling protein
Organism
Macaca nigra
Length
132 amino acids
Function
Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment) (By similarity).
Mass
14.633 kDa
Sequence
MDVTRLLLATLLVFLCFFTAYSHPPPEEKLRDDRSLRSNSSVNLLDFPSVSIVALNKNSKQISRKEAEKKRSSKKEASMKKVARPRTPLSAPCVATRDSCKSPAPACCDPCASCQCRFFRSACSCRVLSLNC

Gene
ASIP
Protein
Agouti-signaling protein
Organism
Macaca nigrescens
Length
132 amino acids
Function
Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment) (By similarity).
Mass
14.511 kDa
Sequence
MDVTRLLLATLLVFLCFFTACSHPPPGEKLRDDRSLRSNSSVNLLDFPSVSIVALNKNSKQISRKEAEKKRSSKKEASMKKVARPRTPLSAPCVATRDSCKPPAPACCDPCASCQCRFFRSACSCRVLSLNC

Gene
ASIP
Protein
Agouti-signaling protein
Organism
Macaca radiata
Length
132 amino acids
Function
Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment) (By similarity).
Mass
14.657 kDa
Sequence
MDVTRLLLATLLVFLCFFTAYSHPPPEEKLRDDRSLRSNSSVNLLDFPSVSIVALNKKSKQISRKEAEKKRSSKKEASMKKVARPRTPLSAPCVATRDSCKPPAPACCDPCASCQCRFFRSACSCRVLSLNC

Gene
ASIP
Protein
Agouti-signaling protein
Organism
Macaca sinica
Length
132 amino acids
Function
Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment) (By similarity).
Mass
14.657 kDa
Sequence
MDVTRLLLATLLVFLCFFTAYSHPPPEEKLRDDRSLRSNSSVNLLDFPSVSIVALNKKSKQISRKEAEKKRSSKKEASMKKVARPRTPLSAPCVATRDSCKPPAPACCDPCASCQCRFFRSACSCRVLSLNC

Gene
ASIP
Protein
Agouti-signaling protein
Organism
Macaca silenus
Length
132 amino acids
Function
Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment) (By similarity).
Mass
14.673 kDa
Sequence
MDVTRLLLATLLVFLCFFTAYSHPPPEEKLRDDRSLRSNSSVNLLDFPSVSIVALNKNSKQISRKEAEKKRSSKKEASMKKVARPRTPLSAPCVTTRDSCKPPAPACCDPCASCQCRFFRSACSCRVLSLNC

Gene
Asip
Protein
Agouti-signaling protein
Organism
Mus musculus
Length
131 amino acids
Function
Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment). Causes hair follicle melanocytes to synthesize phaeomelanin instead of black or brown pigment eumelanin and produces hairs with a subapical yellow band on an otherwise black or brown background when expressed during the mid-portion of hair growth.
Mass
14.313 kDa
Sequence
MDVTRLLLATLVGFLCFFTVHSHLALEETLGDDRSLRSNSSMNSLDFSSVSIVALNKKSKKISRKEAEKRKRSSKKKASMKKVARPPPPSPCVATRDSCKPPAPACCDPCASCQCRFFGSACTCRVLNPNC

Gene
ASIP
Protein
Agouti-signaling protein
Organism
Sus scrofa
Length
131 amino acids
Function
Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment) (By similarity).
Mass
14.498 kDa
Sequence
MDVTRLLLATLLVCLCFFTASSHLAPEEKSKDERSLRSNSSMNLLDFPSVSIVALNKKSKKISRKEAEKRSSKKKASMKKVAQPRPPRPAPCVANRDSCKPPALACCDPCAFCQCRFFRSACSCRVLNPTC

Gene
Asip
Protein
Agouti-signaling protein
Organism
Rattus norvegicus
Length
131 amino acids
Function
Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment).
Mass
14.276 kDa
Sequence
MDVTRLLLATLVGFLCFLTVHSHLVFEETLGDDRSLKSNSSINSLDFSSVSIVALNKKSKKISRKEAEKRKRSSKKKASIKKVARPPPPSPCVATRDSCKPPAPACCNPCASCQCRFFGSACTCRVLNPNC

Gene
ASIP
Protein
Agouti-signaling protein
Organism
Vulpes vulpes
Length
131 amino acids
Function
Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment) (By similarity).
Mass
14.449 kDa
Sequence
MNIFRLLLATLLVSLCFLTAYSHLAEEKPKDDRSLRSNSSVNLLDFPSVSIVALNKKSKKISRKEAEKKRSSKKKASMKNVARPRPPPPNPCVATRNSCKSPAPACCDPCASCQCRFFRSACTCRVLSPSC

Gene
ASIP
Protein
Agouti-signaling protein
Organism
Canis lupus familiaris
Length
131 amino acids
Function
Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment).
Mass
14.505 kDa
Sequence
MNIFRLLLATLLVSLCFLTAYSHLAEEKPKDDRSLRSNSSVNLLDFPSVSIVALNKKSKKISRKEAEKKRSSKKKASMKNVARPRPPPPTPCVATRNSCKSPAPACCDPCASCQCRFFRSACTCRVLSPRC