Protein
MICOS complex subunit MIC27
Function
Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Specifically binds to cardiolipin (in vitro) but not to the precursor lipid phosphatidylglycerol. Plays a crucial role in crista junction formation and mitochondrial function.
Similarity
Belongs to the apolipoprotein O/MICOS complex subunit Mic27 family.
Sequence
MAALRMGKLTTMPTGLIYASISVHVAKEEESKKQLVKPEQLPIYTAPPLQSKYVEEQPGHLQMGFASIRTTTSRYIGWCKGVYVFVKNGIMDTVQFGKDAYVYLKNPPRDFLPKIGVITVSGLAGFISARKGSRFKRIAYPLGLATLGATVCYPVQSVIIAKVAGKKAYATSQQMYEAVKSLWTKNNKKLPEHKEKTKLGSADETETPAETTHNLKHSVPLPAELSSETKTKSTSGATQFMPDPKLMDHGQSHPEDIDMYSTRS