api5

Apoptosis inhibitor 5 homolog

606 amino acids

May be an antiapoptotic factor.

Belongs to the API5 family.

68.973 kDa

METTTTTTTAAATKGTNDAMETSSSTTATPTTATVVPQVVRNDEYINTFYDIANKLDTNPSFPDDDKLFSKIIELSSKTKQTKKLSPQFISKYFKRFPTLQEKAIDCLIDLFDSSDEDVIMRVNALKAIPTICRDNPDHIAKLVDILSQLLNTDSKVEAEHTKNSLIELYKLNSVTTLNSFLTFLESEESSMEDQPASSTLLSFLKESIIPLVRTEYSKSSIETQTFFRVRILKLIAKCTSTTELDLLFQLLECFTQYKVQETITDLETNVLPVIESQSLDTIRKKLINFTKILLFKSKKPHTEINSNKLFDLYLNKIFPKVNELDETNKTELVSVFSQVTPHMTQEISMQFLEPVYNLFKATVPSKTTTPVADVDLQFTIVEALLFALSSIGSKSTSSLCKLCGFKLVTGQPSDMNADPVKYEDFLGRHRFLDEKCRETLGKAKKAIPNLGNPKDKAQLKLAQKTLLSTQNILTIMQNLLKSPPVTNINNLVISSTIFKGKQNLIHNVSPVFKPQQHQHQHQQQQVQQKQYQKYQAQQQQQQNIPIQRNQQQQQQQKSNRYQPYVTPGRRHQDLDKPKQDGVEVHYYSEKHNKPSSFKGRGPKSY

API5

Apoptosis inhibitor 5-like protein API5

537 amino acids

Putative anti-apoptotic factor involved in the regulation of tapetal programmed cell death (PCD) and degeneration during anther development. Interacts directly with the DEAD-box ATP-dependent RNA helicases AIP1 and AIP2 that form dimers and bind the promoter region of the cysteine protease CP1 involved in tapetum PCD.

Belongs to the API5 family.

59.986 kDa

MAASDADAAEVERLYELGERLSSAKDKSQHAADYEAIISAVKGQSVKAKQLAAQLIPRFFRSFPALAPRAMEAMFDLVDMEELATRIQAIRGFPLLAKDAEFVSKIADILGQLLASEENVERDAVHKALMSLIRQDVKSSLQPLFKHVESGSEIREKVICFLKDKVFPVKAELLKPQAEMERYITDLIKKSVLDVTGLEFKLFMDFLRSLSIFGDSAPRESFQELIEIIQAQADLDAQFNVSDIDHIERWTSCMYMALPIFMRGGSSSKFLNYFVKQIVPVFDKIPEEKKLDLLKTVAASSPYATAQDARQLLPPVVQLLKKYMPGKKVEDINHNYVECLMYIFHHLAHKTPNTTNSLCGYKIVTGQPSDRLGEDFSEHYKDFTERLTGTEETVRAVSKRLTQGMADFNKAISSAKTEEEKTKIKSDQQKSTMTMRAYNNILAMAQPLRAKSPLFIGDKKITLSWMEQPKKPAPTTTGGKRSQPATNGNTPASKKGRGEGAARNQLVNRAFEGLSRGGRGSGRGRGRGGRGRGWGYR

API5

Apoptosis inhibitor 5

524 amino acids

Antiapoptotic factor that may have a role in protein assembly. Negatively regulates ACIN1. By binding to ACIN1, it suppresses ACIN1 cleavage from CASP3 and ACIN1-mediated DNA fragmentation. Also known to efficiently suppress E2F1-induced apoptosis. Its depletion enhances the cytotoxic action of the chemotherapeutic drugs.

Belongs to the API5 family.

59.005 kDa

MPTVEELYRNYGILADATEQVGQHKDAYQVILDGVKGGTKEKRLAAQFIPKFFKHFPELADSAINAQLDLCEDEDVSIRRQAIKELPQFATGENLPRVADILTQLLQTDDSAEFNLVNNALLSIFKMDAKGTLGGLFSQILQGEDIVRERAIKFLSTKLKTLPDEVLTKEVEELILTESKKVLEDVTGEEFVLFMKILSGLKSLQTVSGRQQLVELVAEQADLEQTFNPSDPDCVDRLLQCTRQAVPLFSKNVHSTRFVTYFCEQVLPNLGTLTTPVEGLDIQLEVLKLLAEMSSFCGDMEKLETNLRKLFDKLLEYMPLPPEEAENGENAGNEEPKLQFSYVECLLYSFHQLGRKLPDFLTAKLNAEKLKDFKIRLQYFARGLQVYIRQLRLALQGKTGEALKTEENKIKVVALKITNNINVLIKDLFHIPPSYKSTVTLSWKPVQKVEIGQKRASEDTTSGSPPKKSSAGPKRDARQIYNPPSGKYSSNLGNFNYEQRGAFRGSRGGRGWGTRGNRSRGRLY

API5

Apoptosis inhibitor 5

523 amino acids

Antiapoptotic factor that may have a role in protein assembly.

Belongs to the API5 family.

58.609 kDa

MPTVEELYRNYGILADATETAGQHKDAYQVILDGVKGGAKEKRLAAQFIPKFFKHFPELADSAINAQLDLCEDEDVSIRRQAIKELPQFATGDNLPRVADILTQLLQSDDSAEFNLVNNALLSIFKMDAKGTLGGLFSQILQGEDIVRERAIKFLSTKLKTLPEEVLTKEVEEFILAESKKVLEDVTGEEFVLFMKILSGLKSLQTVSGRQQLVELVAEQADLEQTFNPSDPDCVDRLLQCTRQAVPLFSKNVHSTKFVTYFCEHVLPNLSALTTPVEGLDIQLEVLKLLAEMSSFCGDMEKLESNLKKLFDKLLEYMPLPPEEAENGENAGGEEPKLQFSYVECLLYSFHQLGRKLPDFLTAKLNAEKLKDFKIRLQYFARGLQVYIRQLRLALQGKTGEALKTEENKIKVVALKITNNINVLIKDLFHIPPSYKSTVTLSWKPVQKADANQKRTSEDTTSSSPPKKASAGPKRDARQIYNPPSGKYSSNLGSFSYEQRGGFRGGRGRGWGGRGNRSRGRIY

Api5

Apoptosis inhibitor 5

504 amino acids

Antiapoptotic factor that may have a role in protein assembly. Negatively regulates ACIN1. By binding to ACIN1, it suppresses ACIN1 cleavage from CASP3 and ACIN1-mediated DNA fragmentation. Also known to efficiently suppress E2F1-induced apoptosis (By similarity).

Belongs to the API5 family.

56.785 kDa

MPTVEELYRNYGILADATEQVGQHKDAYQVILDGVKGGTKEKRLAAQFIPKFFKHFPELADSAINAQLDLCEDEDVSIRRQAIKELPQFATGENLPRVADILTQLLQTDDSAEFNLVNNALLSIFKMDAKGTLGGLFSQILQGEDIVRERAIKFLSTKLKTLPDEVLTKEVEELILTESKKVLEDVTGEEFVLFMKILSGLKSLQTVSGRQQLVELVAEQADLEQAFSPSDPDCVDRLLQCTRQAVPLFSKNVHSTRFVTYFCEQVLPNLSTLTTPVEGLDIQLEVLKLLAEMSSFCGDMEKLETNLRKLFDKLLEYMPLPPEEAENGENAGNEEPKLQFSYVECLLYSFHQLGRKLPDFLTAKLNAEKLKDFKIRLQYFARGLQVYIRQLRLALQGKTGEALKTEENKIKVVALKITNNINVLIKDLFHIPPSYKSTVTLSWKPVQKVEIGQKRTSEDTSSGSPPKKSPGGPKRDARQIYNPPSGKYSSNLSNFNYERSLQGK

API5

Apoptosis inhibitor 5

504 amino acids

Antiapoptotic factor that may have a role in protein assembly. Negatively regulates ACIN1. By binding to ACIN1, it suppresses ACIN1 cleavage from CASP3 and ACIN1-mediated DNA fragmentation. Also known to efficiently suppress E2F1-induced apoptosis (By similarity).

Belongs to the API5 family.

56.77 kDa

MPTVEELYRNYGILADATEQVGQHKDAYQVILDGVKGGTKEKRLAAQFIPKFFKHFPELADSAINAQLDLCEDEDVSIRRQAIKELPQFATGENLPRVADILTQLLQTDDSAEFNLVNNALLSIFKMDAKGTLGGLFSQILQGEDIVRERAIKFLSTKLKTLPDEVLTKEVEELILTESKKVLEDVTGEEFVLFMKILSGLKSLQTVSGRQQLVELVAEQADLEQTFNPSDPDCVDRLLQCTRQAVPLFSKNVHSTRFVTYFCEQVLPNLGTLTTPVEGLDIQLEVLKLLAEMSSFCGDMEKLETNLRKLFDKLLEYMPLPPEEAENGENAGNEEPKLQFSYVECLLYSFHQLGRKLPDFLTAKLNAEKLKDFKIRLQYFARGLQVYIRQLRLALQGKTGEALKTEENKIKVVALKITNNINVLIKDLFHIPPSYKSTVTLSWKPVQKVEIGQKRASEDTTSGSPPKKSSAGPKRDARQIYNPPSGKYSSNLGNFNYERSLQGK