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APC1

Gene
APC1
Protein
Anaphase-promoting complex subunit 1
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Length
1748 amino acids
Function
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C is thought to confer substrate specificity and, in the presence of ubiquitin-conjugating E2 enzymes, it catalyzes the formation of protein-ubiquitin conjugates that are subsequently degraded by the 26S proteasome. In early mitosis, the APC/C is activated by CDC20 and targets securin PDS1, the B-type cyclin CLB5, and other anaphase inhibitory proteins for proteolysis, thereby triggering the separation of sister chromatids at the metaphase-to-anaphase transition. In late mitosis and in G1, degradation of CLB5 allows activation of the APC/C by CDH1, which is needed to destroy CDC20 and the B-type cyclin CLB2 to allow exit from mitosis and creating the low CDK state necessary for cytokinesis and for reforming prereplicative complexes in G1 prior to another round of replication.
Similarity
Belongs to the APC1 family.
Mass
196.162 kDa
Sequence
MTSKPSTRNDYLPRETHNGEYTGDSPEWQLQINITNKIGGINGDIWLSRDGRSVKWCIEDQCLRQFTYNQKIIKAGYIDFEKTPDCFVVVLSDIAHVYMLKNGGSTTVCFPFQIGNAFWYANGVILERETSASFMDGGYDLKPIEFDLKHKYITLTDPMAPFGLISITNTFKGGINSASGNKTDILQDFQLVLFPSDKDKCIAVFLDRNSKVLRFYYSRILSSDQSRKGELTISSTKKTGLDAAGNSQKSGGISKDLRKFSHLTRRSTSINSNSHDFNAAERVLSGNVGNASGRTDIFALPSSCSRRSLSATLDRMGNNIAPTNRAAPSGFFDSSSANTATHSNITPVSQPMQQQQQEYLNQTATSSKDIVLTEISSLKLPDDIIFTSRRLSSILSKLKFLSLRFERREGLLIFHEPTHFCKIWLIDLLPDVLDSIPFKIYGNSPQNMIRLENLKLKEPSRIQAMYIHELLESCLILVSEGQNKEEYKACLYDPFVKITSPSKNISEELTKQNSLPSLQKLFPYPETSFTKLCFEAVKYITSPAFNISFIFLWQSAYSILLSRANDDVVGGLKMEHDAFSLVLSLLILPIPSSSAQEYQEYKEIYERDLFQHLKQDSEITSSVLPRIVIGLHLIREEYSLNVLCRNEHALLGQFLRFATAAMGWPDLWQSYYVPKMDSESKTFLHPREQNSTFFHPLDEPPSITKSLYSITENSSIPLCPFISFSRLVATDTQVELRITPRSFKILGLYELVHSPNFLPDYVLGILSSFKVDKDELQTYPLGILVPLQNILKILEDKLSEVRDNLELLDRADLQRCSAIINSIRSDSKEVLKRGQRDSYMLCKVPLAKNRSSLSKKPSDIYSILSEIVKSASQVPLDGSAMRMSNIQDDEDIDEGRSLKLNAGLIFSEDKRFTHVVSLLAYYRPTKTQFFTTKTEYAQILAQKKYFAKIMALRTCTNGVGWGAVAYATEKPISTQKWVIQPLNLISVFPDDTKITVKAPEDIAHDIVEWGQFHAGVSSGLRISKKATGITGSWIAFNKPKELDAYHGGFLLGLGLNGHLKNLEEWHIYNYLSPRNTHISIGLLLGMSSSMKGSMDSKLIKVISVHLVAFLPSGSSDLNIDLKLQTAGIIGMGMLYLNSRHKRMSDSIFAQLVSLLNVNDEMVADEEYRLAAGISLGLINLGAGQTKLRKWDSSLLGLGDDLPEDVYDSSDVEQNVMYEDLTTKLLEIVTSTYDVENDWIPENSQIGAVIAIMFLFLKSNNFGISNMLKVDLKEILKANINTRPELLMYREWASNMILWEFIGDDLSFIMKDVDIGVKFSELNTDLLPIYYTMAGRILAMGIRFASTGNLKIRNILLSLVDKFLPLYQYPGKQNLDFRLTISVINVLTNVIVVSLSMVMCASGDLEVLRRVKYLHEVASGPYSDLFQEIPSSKSDVSGVTQVTSNTNTPGNSDRERVDETAASLDDERSSNGSDISDPTAYLEDKKDIDDHYGKFISTNLALGFLFLGSGQYALNTSTLESIAFLSMSVLPTYTTPHPLQELKHFWSMAVEPRCLVIKDISTGDAVNNVPIELVVEEDVEKEEVIREISTPCLLPDFSKIKSIRVKMHGYFPLEVNFTKDYSASDFFSGGTIIYIQRKSESVFENKASFRNVEDIHVALKRKAAESKNYSRLNLKNEQGNTTSSQLVESLGIQDLTMVELDTLLSAGNNTALTDSESYNLGLLCSDKNSGDILDCQLELWYKSFGPHDE

Gene
APC1
Protein
Anaphase-promoting complex subunit 1
Organism
Arabidopsis thaliana
Length
1678 amino acids
Function
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex controls several key steps in the cell cycle by mediating ubiquitination and subsequent degradation of target proteins such as cyclins. The APC/C complex is required for the female gametophyte development and is involved in several aspect of development by controlling cell division and cell elongation. Involved in the control of endoreduplication (By similarity).
Similarity
Belongs to the APC1 family.
Mass
186.276 kDa
Sequence
MPPGVRQLTVLGKFKPFGLIAEATDGKSPDDSYQYFLFDPELTGERDDADGNDANFSRQREHELFIRDNCNVRKGYALVEANFIGYWYNACWSNLGRGTEAFLCVLQIACLTIYNTSGEVVSVPLMRTVKSIWPLPCGLLLEQAGEVNPPSHVPFSPVSPILGSREMLRQRKEVGNSSPQNFHSPVAHDLISKRDMPCMSSHLILRDPLEEPGPTYVEERGKLTIMKDYDERTIWTSDRLPLMTSYNKGKMQHSVWAAEFIESNLEASASCSSGIVPDAVLSKRVSFRRIWQAKGAKKAASKVFLATDNSVPVICFLILEQKKLLSVGLQTVEINNEILFDVKPDISWSVSAIAAAPVVVTRSQVKIGLLPHLDIIVLSPENDLFLYSGKQCLCRYVLPSWLGESIGSGDGESAKTDSGFRNLKITGLSDAVLGSINLSVNHSQIFRCALTGKPSSSLANDCIAAIAEGLRSDLYSLFLSLLWGDGHSDLQGSSIHFEWEALCNIFLEICQKPTVVHRKQPKTASESSWEFLLISKFHKTYSRFHNGITSINRLDLEGIVPFDSKICSEETLGSSCELMVQSLDCLHAVYESLKMDNLRKQDLHHLAVLLCNIAKFLDEKCYLDYYIRDFPRLSTTIGACTTLSSSRKPPNLFRWLENCLRRGCLSTNFDDLPDLIRRDGCSIVSWARKVVSFYSVLFGDKPEGRTLSSGVPCNIAPGSYSCNEELTILAMAGERFGLHQLDLLPSGVSLPLRHALDSCRESPPADWPAIAYVLLGREDMALSVFRNFSSSKEFEMQSNTSLISMSIPYMLHLHPVIVPSSESIGLENTKIEDTNSVDGSVIDGMEHIFNSYTQLRYGRDLRLNEVRRLLCSARPVVVQTAANPTISDQEQQQAFTVPKLVLAGRLPSQQNAIVNLDPNIRNIQELKTWPEFHNAVAAGLRLAPLQGKVSRTWIRYNKPGEPNAVHAGLLFGLGLQGYLHVLNLSDIYQYFTQDHESTTVGLMLGLAASYRGTMQPDIAKALFFHVPARYQASYTEFEIPTLLQSAALVSVGMLFEGSAHQQTMQLLLGEIGRRSAGDNVLEREGYAVSAGFSLGLVALGRGGDALGSMDSLVNRLLLYLGAKEERSILVPSLEDHRSAAQITDGSTSNVDITAPGAIIALTLMYLKTESEVIFSKLSIPQTHYDLECVRPDFIMLRVIARNLIMWSRICPTCDWIQSQVPEVVKNGISQLRDDMDNMYEVDVEALVQAYVNIVAGACISLGLRFAGTRDGNARDLLNSYALYLLNEIKPLSATPGNAFPRGISKFVDRGTLEMCLYLIIISLSVVMAGSGDLQVFRLLRFLRSRNSADGHANYGTQMAVSLATGFLFLGGGMRTFSTNNGSLAMLLITLYPRLPSGPNDNRCHLQAFRHLYVLATEARWLQTIDVDSGLPVYAPLEVTVKETKLYSETKFCEITPCILPERAILKRICVCGPRYWPQQIELVFGLRTLGESNLIANSHRELDSDSVDHLVSTFSSDPSLIAFAQLCCDKSWNNSFDFLILDLILWSQVALAYNEAVSTGRLASSGGFVQSIFLASLRKRCEEVLNCSTELKINLRNYLTSEAWPYDKNSKLQKDIIILSWYLKWFNVPSPSIIKAAVEKIKSKSKNSTSAIPLLRLLLPNTHISVIGEIDRVFFPSN

Gene
apc1
Protein
Acetophenone carboxylase alpha subunit
Organism
Aromatoleum aromaticum (strain EbN1)
Length
658 amino acids
Function
Catalyzes the carboxylation of acetophenone to form 3-oxo-3-phenylpropanoate (benzoylacetate) in the anaerobic catabolism of ethylbenzene. Also carboxylates propiophenone at the same rate and 4-acetyl-pyridine at lower rates.
Similarity
Belongs to the oxoprolinase family.
Mass
69.867 kDa
Sequence
MYTVDIDTGGTMTDALVSDGEQRHAIKVDTTPHDYTVSFNGCLSEAAKRLGYPSTEAFLAKVGMIRWSSTITTNVLGERRGSKVGLLVTEGNEENLYGTVQSPVVGELVDERNIIGLPSNPTAVDILSGVKQLLEGGVRRICVCLANAFPDNGAEREIKAVIEDQYPDHIIGAVPVLLGSEMAPLRHDQTRVHYSLMNAYTHTQLATSLFKAEDLLRDDHNWTGPLLIGNTNGGVARIGKTKSVDTIESGPVFGTFGGAYMARLYGLKDVVCFDVGGTTTKASIIRDGQPMFQRGGELMEVPVQSSFAMLRSAVVGGGSIARVRDKSVTLGPESMGAAPGPACYGLGGNEATLTDALLALGYLDPNNFLGGRRQLKVDLARAAIERNVAKPLGVSLEVAALSIRDEAVAMMTELLQATLAEAKLTAQDAALFAFGGNGPMFAAFVAERLGVQAAYAFNLGPVFSAFGSAISDVVHVYERGVDLRWNATVKGQLLPTLDALQTQAERDLKGESFDPAKAAYVWELDFGTTEAEVSTVRAELAQSAASTVLDALTQAVTAAGVASLPLLGARLSSRFVVGAHGMKKRADRVPAEAPASREMRFNGASEAASPVYRWETMNVGDIAVGPAVVNGSTLTCPIPPRWQLRVDDYGNAELSRAQ

Gene
APC1
Protein
Calcium-dependent mitochondrial ATP-magnesium/phosphate carrier protein 1
Organism
Arabidopsis thaliana
Length
478 amino acids
Function
Calcium-dependent mitochondrial carrier protein that catalyzes the import of ATP co-transported with metal divalent cations across the mitochondrial inner membrane in exchange for phosphate (Pi) (PubMed:22062157, PubMed:28695448, PubMed:26140942, PubMed:26444389). Can transport phosphate, AMP, ADP, ATP, adenosine 5'-phosphosulfate and, to a lesser extent, other nucleotides (PubMed:26140942, PubMed:26444389). Binds calcium ions Ca(2+) (PubMed:22062157). Mediates also calcium uptake (By similarity).
Similarity
Belongs to the mitochondrial carrier (TC 2.A.29) family.
Mass
53.275 kDa
Sequence
MEAEKSKQNPGKKPVEATMEHVLVALRETKEKREIRIQKLFEFFDNSKLGFLDDTQIEKGLSSLSIPPKYRYASDFLKVCDSNRDGRVDYQEFRRYMDAKELELYKIFQAIDIEHNGDICPAELWEALDKAGIKIKDEELASFMEHVDKDNNGIITFEEWRDFLLLNPHEATIENIYHHWERVCLIDIGEQAVIPDGISAHAQRSKLLLAGGIAGAVSRTATAPLDRLKVALQVQRTNLGVVPTIKKIWREDKLLGFFRGNGLNVAKVAPESAIKFAAYEMLKPIIGGADGDIGTSGRLLAGGLAGAVAQTAIYPMDLVKTRLQTFVSEVGTPKLWKLTKDIWIQEGPRAFYRGLCPSLIGIIPYAGIDLAAYETLKDLSRAHFLHDTAEPGPLIQLGCGMTSGALGASCVYPLQVIRTRMQADSSKTSMGQEFLKTLRGEGLKGFYRGIFPNFFKVIPSASISYLVYEAMKKNLALD