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AP4B1

Gene
ap4b1
Protein
AP-4 complex subunit beta
Organism
Dictyostelium discoideum
Length
838 amino acids
Function
Probable component of an adaptor protein complex. Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways.
Similarity
Belongs to the adaptor complexes large subunit family.
Mass
96.507 kDa
Sequence
MTSTANYNNSGKDSYFSEIKKSELGLIKNNLSTAINERNADKIKDILQRIIYYMTIGMDVSVLFPDVIMVASSNDIIIKKLVYLYIVHYSKSNPDLLLLVVNTLRRDCIDRNPIIRGLALRSLCSLDSKNTLEYATIEINRSLTDFSGYVRKTALLGLAKLYHLSKEAFDLDIIIPKIFDMIMDQDPQVIVNAVSTLNEIKPGWSFTFDLVQHLMIKFKEFNEWSQCIILECLSRYTPSSEDESLDILNLLDDRLSHSNSALTLSTIKIFLKYTDEFEEIQEQVYERIKEPLITLMESSESNETSFTILHHIHLLMSRSPRLFNRYYKHFYCKFDDPLYIKTLKVQVLKEIASNQTFIESIDEILQELSEYVYEGDHSLCKQSINAITVIAQKHKNTQEKYPIDESVLEKIFLPYLSVSSNLGGAGDDNISINEGILSFILISLKDFLRVFPKHLKTVLPYINENLIGIGSVSNYTLPPSANESVLWMLGESPNSQVNSPYIIEEFFNEKFDQQPTFVKTQLLTTSLKVFFDRPGEMLPILKRILKKCCSDLSQDPGLHEISLFYSRIILLLDIDKAASIINSSKQTTSINTFLEDEINEYRDKIFDEFNTLSVLFGKHSTKFIKNKKQIENEKLQFLENQKNYLLSITDGNQNNNQNNNQNNNQNNNQNNNQNNQNNNNQNNNSKQLLKEIESSPNNLIDTFILDQQPELSPELFQSLWLSLEDGHKIDIQLDSPIDNSEIESVMSKQGIICLAFGSVDQQTKLYYYARQNLSFDIDFNSEQNQQQPQPIFIIEILIDENTLLMSILFKSPILKTLHNKFIPKFLSILSIPIPKIFN

Gene
AP4B1
Protein
AP-4 complex subunit beta-1
Organism
Homo sapiens
Length
739 amino acids
Function
Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways (PubMed:10066790, PubMed:10436028). AP-4 forms a non clathrin-associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper asymmetric localization of somatodendritic proteins in neurons. AP-4 is involved in the recognition and binding of tyrosine-based sorting signals found in the cytoplasmic part of cargos, but may also recognize other types of sorting signal (Probable).
Similarity
Belongs to the adaptor complexes large subunit family.
Mass
83.26 kDa
Sequence
MPYLGSEDVVKELKKALCNPHIQADRLRYRNVIQRVIRYMTQGLDMSGVFMEMVKASATVDIVQKKLVYLYMCTYAPLKPDLALLAINTLCKDCSDPNPMVRGLALRSMCSLRMPGVQEYIQQPILNGLRDKASYVRRVAVLGCAKMHNLHGDSEVDGALVNELYSLLRDQDPIVVVNCLRSLEEILKQEGGVVINKPIAHHLLNRMSKLDQWGQAEVLNFLLRYQPRSEEELFDILNLLDSFLKSSSPGVVMGATKLFLILAKMFPHVQTDVLVRVKGPLLAACSSESRELCFVALCHVRQILHSLPGHFSSHYKKFFCSYSEPHYIKLQKVEVLCELVNDENVQQVLEELRGYCTDVSADFAQAAIFAIGGIARTYTDQCVQILTELLGLRQEHITTVVVQTFRDLVWLCPQCTEAVCQALPGCEENIQDSEGKQALIWLLGVHGERIPNAPYVLEDFVENVKSETFPAVKMELLTALLRLFLSRPAECQDMLGRLLYYCIEEEKDMAVRDRGLFYYRLLLVGIDEVKRILCSPKSDPTLGLLEDPAERPVNSWASDFNTLVPVYGKAHWATISKCQGAERCDPELPKTSSFAASGPLIPEENKERVQELPDSGALMLVPNRQLTADYFEKTWLSLKVAHQQVLPWRGEFHPDTLQMALQVVNIQTIAMSRAGSRPWKAYLSAQDDTGCLFLTELLLEPGNSEMQISVKQNEARTETLNSFISVLETVIGTIEEIKS

Gene
Ap4b1
Protein
AP-4 complex subunit beta-1
Organism
Mus musculus
Length
738 amino acids
Function
Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways. AP-4 forms a non clathrin-associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system (By similarity). It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper asymmetric localization of somatodendritic proteins in neurons (PubMed:18341993). AP-4 is involved in the recognition and binding of tyrosine-based sorting signals found in the cytoplasmic part of cargos, but may also recognize other types of sorting signal (By similarity).
Similarity
Belongs to the adaptor complexes large subunit family.
Mass
82.976 kDa
Sequence
MPYLGSEDVVKELKKALCNPHIQADRLRYRNVIQRVIRHMTQGLDMSDVFMEMVKASATVDIVQKKLVYLYMGTYAPLKPDLALLAINTLCKDCSDPNPMVRGLALRSMCSLRMPGVQEYIQQPVVNGLRDKASYVRRVAVLGCAKMHNLHGDSEVDGALVNELYSLLRDQDPIVVVNCLRSLEEILKQEGGVVINKPIAHHLLNRMSKLDQWGQAEVLNFLLRYQPRSEEELFDILNLLDSYLKSSSTGVVMGATKLFLILAKKFPHVQTDVLVRVKGPLLAACSSESRELCFAALCHVRQVLHSLPGHFSSHYKKFFCSYSEPHYIKLQKVEVLCELVNDENVQQVLEELRGYCTDVAADFAQAAIFAIGSIAKTYTDQCVQILTELLGLRQEHITTVVVQTFRDLVWLCPQCTEAVCQALPGCEENIQDSEGKQALIWLLGVHGEKIPNAPYVLEDFVDNVKSETFPAVKMELLTALMRLVLSRPAECQDMLGRLLHYCIEEEKDMAVRDRGLFYYRLLLVGIDKVKQILCSPKSDPSLGLLEDQPERPVNSWASDFNTLAPVYGRAHWATISKCQQVERHRLELPHNASFATSGHLISEENKEGAQEPDSDTLMLVPNLQLTAEYFEKTWLSLRVSYQQVFPWQGEVQPDTLQMALKVVNIQTIAMSRAGAQPWKAYLSAQDDTGGLFLAELLLKPENSEMQISVKQSKARTESLHGFVSVLETVIGTVGDIKS