AP3D1

AP-3 complex subunit delta-1

1207 amino acids

Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. Involved in process of CD8+ T-cell and NK cell degranulation. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.

Belongs to the adaptor complexes large subunit family.

136.39 kDa

MALKMVKGSIDRMFDKNLQDLVRGIRNHKEDEAKYISQCIDEIKQELKQDNIAVKANAVCKLTYLQMLGYDISWAAFNIIEVMSASKFTFKRIGYLAASQCFHEGTDVIMLTTNQIRKDLSSPSQYDTGVALTGLSCFVTPDLARDLANDIMTLMSHTKPYIRKKAVLIMYKVFLKYPESLRPAFPRLKEKLEDPDPGVQSAAVNVICELARRNPKNYLSLAPLFFKLMTSSTNNWVLIKIIKLFGALTPLEPRLGKKLIEPLTNLIHSTSAMSLLYECVNTVIAVLISLSSGMPNHSASIQLCVQKLRILIEDSDQNLKYLGLLAMSKILRTHPKSVQAHKDLVLQCLDDKDESIRLRALDLLYGMVSKKNLMEIVKKLMTHVDKAEGTTYRDELLTKIIDICSQSNYQHITNFEWYISILVELTRLEGTRHGHLIAAQMLDVAIRVKAIRRFAVAQMSALLDSAHLVASSPQRSGICEVLYAAAWICGEFSEHLQEPQQTLEAMLRPKVTTLPGHIQAVYVQNVVKLYAAILQQKEQAADTSAAQEVTQLLVERLPQFVQSADLEVQERASCILQLVKHVQKLQAKDVPVAEEVSALFAGELNPVAPKAQKKVPVPEGLDLDAWINEPLSDSESEDEKPKAMFQDEEQRHTKPRAPEADEQELARRREARRQEQANNPFYIKSSPSPQKRYQDAPGVEHIPVVQIDLSVPLKVPGMPLSDQYVKLEEERRHRQRLEKDKRKKKKRERERRGTRRHSSLHTESDEDIAPAQRVDIVTEEMPENALPSDEDDKDPNDPYRALDIDLDKPLADSEKLPVQKHRNAETSKSPEKEDVPLVEKKSKKPKKKEKKHKEKEREKKKKEVEKGEDLDFWLSTTPPAATPALEELEVNTTVTVLKEGQEEPRGEEQDAEEDREQDLEKKPSKHKKKKHKKDKEERPKDKRKSKKKVPPADEEAAEPVENGTLEEEPLPPMSSYILLAENSYIKMTYDVQGSLQKDSQVTVSVVLENQSDSFLKSMELNVLDSLNARLARPEGSSVHDGVPVPFQLPPGISNEAQFVFTIQSIVMAQKLKGTLSFIAKNDEGSTHEKLDFKLHFTCTSYLVTTPCYSDAFAKLLESGDLSMSSIKVDGISMSFHNLLAKICFHHRFSVVERVDSCASMYSRSIQGHHVCLLVKKGEKSVSVDGKCSDPTLLSNLLEEMKETLATC

Ap3d1

AP-3 complex subunit delta-1

1199 amino acids

Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes (By similarity). Involved in process of CD8+ T-cell and NK cell degranulation (By similarity). In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals (PubMed:21998198).

Belongs to the adaptor complexes large subunit family.

135.081 kDa

MALKMVKGSIDRMFDKNLQDLVRGIRNHKEDEAKYISQCIDEIKQELKQDNIAVKANAVCKLTYLQMLGYDISWAAFNIIEVMSASKFTFKRVGYLAASQCFHEGTDVIMLTTNQIRKDLSSPSQYDTGVALTGLSCFVTPDLARDLANDIMTLMSHTKPYIRKKAVLIMYKVFLKYPESLRPAFPRLKEKLEDPDPGVQSAAVNVICELARRNPKNYLSLAPLFFKLMTSSTNNWVLIKIIKLFGALTPLEPRLGKKLIEPLTNLIHSTSAMSLLYECVNTVIAVLISLSSGMPNHSASIQLCVQKLRILIEDSDQNLKYLGLLAMSKILKTHPKSVQSHKDLILQCLDDKDESIRLRALDLLYGMVSKKNLMEIVKKLMTHVDKAEGTTYRDELLTKIIDICSQSNYQHITNFEWYISILVELTRLEGTRHGHLIAAQMLDVAIRVKAIRKFAVSQMSSLLDSAHLVASSTQRNGICEVLYAAAWICGEFSEHLQGPQQTLEAMLRPKVTTLPGHIQAVYVQNVVKLYASILQQKEQAADTEAAQEVTQLLVERLPQFVQSADLEVQERASCILQLVKHVQKLQAKGVPVAEEVSALFAGELNPVAPKAQKKVPVPEGLDLDAWINEPPSDSESEDEKPKAIFHEEEPRHTRRRQPEEDEEELARRREARKQEQANNPFYIKSSPSPQKRYQDAPGVEHIPVVQIDLSVPLKVPGMPMSDQYVKLEEQRRHRQRLEKDKKRKKKEKGKRRHSSLPTESDEDIAPAQRVDIITEEMPENALPSDEDDKDPNDPYRALDIDLDKPLADSEKLPVQKHRNAEAVKSPEKEGVLGVEKKSKKPKKKEKKTKEREREKKDKKGEDLDFWLSTTPPPAAAPIPAPSTEELAASTITSPKDECEVLKGEEEDHVDHDQERKSSRHKKKKHRKEKEKEERPRDKKKAKKKQVAPLENGAAAEEEEEPIPPMSSYCLLAESPYIKVTYDIQASLQKDSQVTVSIILENQSSSFLKNMELNVLDSLNTKMTRPEGSSVHDGVPVPFQLPPGVSNEAQFVFTIQSIVMAQKLKGTLSFIAKDDEGATHEKLDFRLHFSCSSYLITTPCYSDAFAKLLESGDLSMNSIKVDGISMSFQNLLAKICFYHHFSVVERVDSCASMYSRSIQGHHVCLLVKKGESSVSVDGKCSDATLLSSLLEEMKTTLAQC

AP3D1

AP-3 complex subunit delta-1

1153 amino acids

Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. Involved in process of CD8+ T-cell and NK cell degranulation (PubMed:26744459). In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals (By similarity).

Belongs to the adaptor complexes large subunit family.

130.158 kDa

MALKMVKGSIDRMFDKNLQDLVRGIRNHKEDEAKYISQCIDEIKQELKQDNIAVKANAVCKLTYLQMLGYDISWAAFNIIEVMSASKFTFKRIGYLAASQSFHEGTDVIMLTTNQIRKDLSSPSQYDTGVALTGLSCFVTPDLARDLANDIMTLMSHTKPYIRKKAVLIMYKVFLKYPESLRPAFPRLKEKLEDPDPGVQSAAVNVICELARRNPKNYLSLAPLFFKLMTSSTNNWVLIKIIKLFGALTPLEPRLGKKLIEPLTNLIHSTSAMSLLYECVNTVIAVLISLSSGMPNHSASIQLCVQKLRILIEDSDQNLKYLGLLAMSKILKTHPKSVQSHKDLILQCLDDKDESIRLRALDLLYGMVSKKNLMEIVKKLMTHVDKAEGTTYRDELLTKIIDICSQSNYQYITNFEWYISILVELTRLEGTRHGHLIAAQMLDVAIRVKAIRKFAVSQMSALLDSAHLLASSTQRNGICEVLYAAAWICGEFSEHLQEPHHTLEAMLRPRVTTLPGHIQAVYVQNVVKLYASILQQKEQAGEAEGAQAVTQLMVDRLPQFVQSADLEVQERASCILQLVKHIQKLQAKDVPVAEEVSALFAGELNPVAPKAQKKVPVPEGLDLDAWINEPLSDSESEDERPRAVFHEEEQRRPKHRPSEADEEELARRREARKQEQANNPFYIKSSPSPQKRYQDTPGVEHIPVVQIDLSVPLKVPGLPMSDQYVKLEEERRHRQKLEKDKRRKKRKEKEKKGKRRHSSLPTESDEDIAPAQQVDIVTEEMPENALPSDEDDKDPNDPYRALDIDLDKPLADSEKLPIQKHRNTETSKSPEKDVPMVEKKSKKPKKKEKKHKEKERDKEKKKEKEKKKSPKPKKKKHRKEKEERTKGKKKSKKQPPGSEEAAGEPVQNGAPEEEQLPPESSYSLLAENSYVKMTCDIRGSLQEDSQVTVAIVLENRSSSILKGMELSVLDSLNARMARPQGSSVHDGVPVPFQLPPGVSNEAQYVFTIQSIVMAQKLKGTLSFIAKNDEGATHEKLDFRLHFSCSSYLITTPCYSDAFAKLLESGDLSMSSIKVDGIRMSFQNLLAKICFHHHFSVVERVDSCASMYSRSIQGHHVCLLVKKGENSVSVDGKCSDSTLLSNLLEEMKATLAKC

ap3d1

AP-3 complex subunit delta

1143 amino acids

Part of the AP-3 complex, an adaptor-related complex which is essential for the compartmentalization of the endocytic pathway.

Belongs to the adaptor complexes large subunit family.

127.858 kDa

MFERTLVDLIRGIRNHKKNETKFINQCINEIKEELKGDMQKKTVAVQKLTYIQMLGFDISWASFKIVEVMSCNKFSSKRIGYLAASQSFNEGTDVIVLATHQIRKDFLSSNQSEAYLALNCLSNICTTDLARELANDILTLLSTQKTHILKRAITVLYKIFLRYPESLRPAFPKLREKLDDPEPSVVSCSVNVICELARRNPKNYLPLAPVLFRILTNTTNNYWMLIKIVKLFAALTPHEPRLGKKLIDPLTNIINSSPSVSLLYECIQTCITGMSDHIPLMKLCISKLRTLIEHNDQNLKYLGLLALNNIMKIHPKAVSEHRDLVLNCLEDDDISIRLRALDLLPGMTSKKNIGDIVFKLLDHLDNAEGQYKEQIIEKIIELCSMGTYQFITDFEWYINILVKLSQIQDSIHGKLIASQLLDVVIRVKIVRAYSTRQMIELLKNPKLMSNPTEGGMCEVLYAAAWIVGEFSGYVNRPIDALEAFLQPRVCVLPSHIQSVYMLNSLKVFSHACAKANGDKIPSLDDDDEEEEAQEEEDQNEITHEIVQECLEIIKSRLTIFTHSIYLNVQERACLINELLSFYTVTKEQGNNISKELISLFTEQLNPVGPKAQKKVPIPEGLDLDEWINDPKHQEPIEEDEDDDIFNTSTSSHQKKHHKHHRGGYDGDDDEDDETNSSHSGHSSSNFNRHPIDIQRQKEERLRKQANNPYMLGGKVSKKLSTNDPENIPVVQLTGDLGHLHVGASSNRPMPSKGSKKTKKHYTIDTTTEMPEGAKESDDEDEKDNKYKNDALSNINLSEPLTASDVLHTSRHRTDIIKEKEREMAMLAKKNAKLSPKSPPSTANYSEVTSPEIAPAKKATKKAAAGSNPPPPPTAKKSSKKPAATSSTTTTTKSTQAAAAVVAPPPVIVKKVLKTILDDDNFKITCEILKVSPSNETDNNQIKLTMKVQNKTDEDMSDVSISLKNPAEQCVSIKNSGEIGVLEADASTTHTELLNVVNVLNSQELQFTLLASPSSSPSITNQLSIDLPFSFFIVATKLPKDKFAEILQKSGQVSAMDSTKITGQSLTMPLVIEKLAQQLSIEVVQAHPNGQTASFYAKTTQNHHIAMLVKEKDGNISFDIKSPQSLLNQILVKEIAQLTFSSK