Protein
AP-2 complex subunit sigma
Function
Component of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. AP2S1/AP17 is a subunit of the plasma membrane adaptor. The complex binds polyphosphoinositides.
Similarity
Belongs to the adaptor complexes small subunit family.
Sequence
MIRFILLQNRQGKTRLAKYYVPLEDSEKHKVEYEVHRLVVNRDPKFTNFVEFRTHKVIYRRYAGLFFSICVDITDNELAYLECIHLFVEILDHFFSNVCELDLVFNFHKVYRYLILDEFILAGELQETSKRQ