ANPEP

Aminopeptidase N

975 amino acids

(Microbial infection) Probable receptor for canine coronavirus (CCoV).

Belongs to the peptidase M1 family.

110.257 kDa

MAKGFYISKALGILAIVLGIAAVSTIIALSVVYAQEKNKNAESSPVSSPVSSPVSSPVSPTNPSTTAATTLAQSKPWNHYRLPKTLIPSSYNVTLRPYLTPNSNGLYTFKGSSTVRFTCKESTSMIIIHSKKLNYTNIQGQRVALRGVGGSQAPAIDRTELVEVTEYLVVHLREPLQVNSQYEMDSKFEGELADDLAGFYRSEYTENGVKKVLATTQMQAADARKSFPCFDEPAMKATFNITLIHPSNLVALSNMLPRGPSVPFTEEPNWNVTEFETTPIMSTYLLAYIVSEFKNVQENTPSNVLIRIWARPSAMDQGHGNYALRVTGPILDFFSRHYDTPYPLNKSDQIALPDFNAGAMENWGLVTYRESALLYDPQSSSIGNKERVVTVIAHELAHQWFGNLVTLEWWNDLWLNEGFASYVEYLGADYAEPTWNLKDLIVLNEVYRVMAVDALASSHPLSSPASEVNTPAQISEVFDSISYSKGASVLRMLSSFLTEDLFKKGVASYLHTFAYQNTIYLDLWNHLQWALGNQTAINLPYTVNAIMDRWILQMGFPVVTVDTTTGTLSQKHFLLDPQSNVTRPSKFNYLWIIPISSVKSGTQQAHYWMPDNAKVQNDLFKTTGDEWVLLNLNVTGYYLVNYDQNNWKKIHTQLQTDLSVIPVINRAQVIHDTFDLASAQIVPVTLALNSTLFLNQETEYMPWEAALSSLSYFKLMFDRSEVYGPMKNYLRKQVTPLFNHFEKITQNWTDHPQTLTEQYNEINAVSTACTYGVPKCKDLVSTLFAEWRKNPQNNPIYPNLRSTVYCNAIAQGGEEEWNFVWEQFRNTSLVNEADKLRSALACSTQVWILNRYLSYTLNPEFIRKQDVISTLSSIASNVIGQSLAWDFIQSNWKKLFEDYGTGSFSFSNLIQAVTRRFSTEFELQQLEQFKANNMDTGFGSGTRALEQALEKTKANIKWVKENKEAVLQWFRENSQ

ANPEP

Aminopeptidase Ey

972 amino acids

Broad specificity aminopeptidase. Degrades a variety of peptides possessing various N-terminal amino acids including hydrophobic, basic and acidic amino acids. Preferentially hydrolyzes small peptides consisting of 4 or 5 amino acids. Hydrolyzes the N-terminal Xaa-Pro bonds in the chicken brain peptide Leu-Pro-Leu-Arg-PheNH2, the substance P fragment Arg-Pro-Lys-Pro and the bradykinin fragment Arg-Pro-Pro-Gly-Phe. Hydrolyzes the N-formylated peptides fMet-Leu-Phe, fMet-Ala-Gly-Ser-Glu and fMet-Nle-Leu-Phe-Nle-Tyr-Lys, but does not hydrolyze peptides with acetylation or pyroglutamic acid at N-terminus. Does not hydrolyze large peptides such as complete substance P, bradykinin or schistoFLRFamide.

Belongs to the peptidase M1 family.

109.132 kDa

MAAGFFISKSVGIVGIVLALGAVATIIALSVVYAQEKNKSSGGSGGSDTTSTTTASTTTTSTTTASTTAAPNNPWNRWRLPTALKPESYEVTLQPFLTPDDNNMYIFKGNSSVVFLCEEATDLILIHSNKLNYTLQGGFHASLHAVNGSTPPTISNTWLETNTQYLVLQLAGPLQQGQHYRLFSIFTGELADDLAGFYRSEYTEGNVTKVVATTQMQAPDARKAFPCFDEPAMKAVFTVTMIHPSDHTAISNMPVHSTYQLQMDGQSWNVTQFDPTPRMSTYLLAFIVSQFDYVENNTGKVQIRIWGRPAAIAEGQGEYALEKTGPILSFFERHYNTAYPLPKSDQVGLPDFNAGAMENWGLVTYRENSLLYDNAYSSIGNKERVVTVIAHELAHQWFGNLVTLRWWNDLWLNEGFASYVEYLGADSAEPTWDIKDLMVLNELYTVMATDALTTSHPLTFREDEINTPAQISEVFDSIAYSKGASVLRMLSDFLTEDVFKEGLQSYLHDFSYNNTVYTDLWDHLQEAVNKNSVPLPDSIGAIMDRWTLQMGFPVVTVNTLTGSVQQSHFLLDSNSTVERPSVFNYTWIVPITWMTPSRTGDRYWLVDVSATNSDFSVGSSTWLLLNLNVSGYFRVNYNQENWDQLLQQLSNNHQAIPVINRAQIIDDAFNLARAQQVSVTLALNTTRFLSGETAYMPWQAALNNLQYFQLMFDRSEVFGAMTKYIQKQVTPLFEYYRTATNNWTAIPSALMDQYNEINAISTACSYGIAECQQLATALYQQWRQNVSNNPIAPNLRSAIYCSAVATGGEEVWDFIWERFLEAPVVSEADKLRTALTCSTETWILQRYLQYTIDPTKIRKQDATSTINSIASNVVGQPLAWDFIRSNWRTLFGQYGGGSFSFSRLISAVTQRFNTEFELKQLEQFKADNQDIGFGSGTRALEQALERTRTNINWVKENKEVVHAWFRAETASS

ANPEP

Aminopeptidase N

967 amino acids

(Microbial infection) In case of feline coronavirus (FCoV) infection, serves as a receptor for FCoV spike glycoprotein. It is as well a receptor for other serogroup I coronaviruses, like canine coronavirus (CCoV), porcine transmissible gastroenteritis virus (TGEV), and human coronavirus 229E (HCoV-229E). Also serves as a receptor for infectious bronchitis virus (IBV, Arkansas 99 serotype) in serogroup III.

Belongs to the peptidase M1 family.

109.424 kDa

MAKGFYISKPVGILAILLGVAAVCTIIALSVVYSQEKNRSTESSTAASTAAPTGPTTTVATTLDQSKPWNVYRLPKTLIPDSYNVTLRPYLTPNNKGLYVFTGTNIVRFTCKESTNIVIIHSKRLNYTSHQGHMVALSGVGGFHPQPVIVRTELVELTEYLVVHLQEPLVAGRQYEMNSEFQGELADDLAGFYRSEYMENGVKKVLATTHMQATEARKSFPCFDEPAMKATFNITIIHPNNLVALSNMLPRGPSVPFGEDPTWKVTEFETTPIMSTYLLAYIVSEFSYVETRAPSGVLIRIWARPSAINQGHGDYALKVTGPILDFFSQHYDTPYPLNKSDQIALPDFNAGAMENWGLVTYRESALLYDRQSSSSGNQERVVTVIAHELAHQWFGNLVTLEWWNDLWLNEGFASYVEYLGADFAEPTWNLKDLMVLNDVYRVMAVDALASSHPLSTPASEINTPAQISEVFDSISYSKGASVLRMLSNFLTEDLFKMGIASYLHTYKYGNTIYLNLWEHLQQVVDKQPTIKLPDTVSAIMDRWILQMGFPVITVDTQTGTISQQHFLLDPQSVVTRPSQFNYLWIVPISSVRSGSPQAHYWLPGVEKAQNDLFKTTANDWVLLNLNVTGYYLVNYDNENWKKIQTQLQTDLSVIPVINRAQVIHDAFNLASAQKVPVTLALNNTLFLIQETEYMPWQAALSSLSYFKLMFDRSEVYGPMKRYLKKQVTPLFNHFERVTKNWTDHPQTLMDQYSEINAVSTACSYGVPECEKLAATLFAQWKKNPQNNPIHPNLRSTVYCNAIAQGGEEEWNFVWEQFLKAELVNEADKLRGALACSNQVWILNRFLSYTLDPNLIRKQDVTSTLSSISSNVVGQTLVWDFVQSNWKKLFQDYGTGSFSFSNLIQAVTRRFSTEFELQQLEQFKKNNMDTGFGSATRALEQALEKTKANLKWVKENKDVVLRWFTENS

ANPEP

Aminopeptidase N

967 amino acids

(Microbial infection) Mediates as well Human cytomegalovirus (HCMV) infection.

Belongs to the peptidase M1 family.

109.54 kDa

MAKGFYISKSLGILGILLGVAAVCTIIALSVVYSQEKNKNANSSPVASTTPSASATTNPASATTLDQSKAWNRYRLPNTLKPDSYRVTLRPYLTPNDRGLYVFKGSSTVRFTCKEATDVIIIHSKKLNYTLSQGHRVVLRGVGGSQPPDIDKTELVEPTEYLVVHLKGSLVKDSQYEMDSEFEGELADDLAGFYRSEYMEGNVRKVVATTQMQAADARKSFPCFDEPAMKAEFNITLIHPKDLTALSNMLPKGPSTPLPEDPNWNVTEFHTTPKMSTYLLAFIVSEFDYVEKQASNGVLIRIWARPSAIAAGHGDYALNVTGPILNFFAGHYDTPYPLPKSDQIGLPDFNAGAMENWGLVTYRENSLLFDPLSSSSSNKERVVTVIAHELAHQWFGNLVTIEWWNDLWLNEGFASYVEYLGADYAEPTWNLKDLMVLNDVYRVMAVDALASSHPLSTPASEINTPAQISELFDAISYSKGASVLRMLSSFLSEDVFKQGLASYLHTFAYQNTIYLNLWDHLQEAVNNRSIQLPTTVRDIMNRWTLQMGFPVITVDTSTGTLSQEHFLLDPDSNVTRPSEFNYVWIVPITSIRDGRQQQDYWLIDVRAQNDLFSTSGNEWVLLNLNVTGYYRVNYDEENWRKIQTQLQRDHSAIPVINRAQIINDAFNLASAHKVPVTLALNNTLFLIEERQYMPWEAALSSLSYFKLMFDRSEVYGPMKNYLKKQVTPLFIHFRNNTNNWREIPENLMDQYSEVNAISTACSNGVPECEEMVSGLFKQWMENPNNNPIHPNLRSTVYCNAIAQGGEEEWDFAWEQFRNATLVNEADKLRAALACSKELWILNRYLSYTLNPDLIRKQDATSTIISITNNVIGQGLVWDFVQSNWKKLFNDYGGGSFSFSNLIQAVTRRFSTEYELQQLEQFKKDNEETGFGSGTRALEQALEKTKANIKWVKENKEVVLQWFTENSK

Anpep

Aminopeptidase N

966 amino acids

Broad specificity aminopeptidase which plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Also involved in the processing of various peptides including peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines (By similarity). May also be involved the cleavage of peptides bound to major histocompatibility complex class II molecules of antigen presenting cells (PubMed:8691132). May have a role in angiogenesis and promote cholesterol crystallization (By similarity).

Belongs to the peptidase M1 family.

109.651 kDa

MAKGFYISKTLGILGILLGVAAVCTIIALSVVYAQEKNRNAENSATAPTLPGSTSATTATTTPAVDESKPWNQYRLPKTLIPDSYRVILRPYLTPNNQGLYIFQGNSTVRFTCNQTTDVIIIHSKKLNYTLKGNHRVVLRTLDGTPAPNIDKTELVERTEYLVVHLQGSLVEGRQYEMDSQFQGELADDLAGFYRSEYMEGDVKKVVATTQMQAADARKSFPCFDEPAMKAMFNITLIYPNNLIALSNMLPKESKPYPEDPSCTMTEFHSTPKMSTYLLAYIVSEFKNISSVSANGVQIGIWARPSAIDEGQGDYALNVTGPILNFFAQHYNTSYPLPKSDQIALPDFNAGAMENWGLVTYRESSLVFDSQSSSISNKERVVTVIAHELAHQWFGNLVTVAWWNDLWLNEGFASYVEYLGADYAEPTWNLKDLMVLNDVYRVMAVDALASSHPLSSPADEIKTPDQIMELFDSITYSKGASVIRMLSSFLTEDLFKKGLSSYLHTYQYSNTVYLDLWEHLQKAVNQQTAVQPPATVRTIMDRWILQMGFPVITVNTNTGEISQKHFLLDSKSNVTRPSEFNYIWIAPIPFLKSGQEDHYWLDVEKNQSAKFQTSSNEWILLNINVTGYYLVNYDENNWKKLQNQLQTDLSVIPVINRAQIIHDSFNLASAKMIPITLALDNTLFLVKEAEYMPWQAALSSLNYFTLMFDRSEVYGPMKRYLKKQVTPLFFYFQNRTNNWVNRPPTLMEQYNEINAISTACSSGLKECRDLVVELYSQWMKNPNNNTIHPNLRSTVYCNAIAFGGEEEWNFAWEQFRNATLVNEADKLRSALACSKDVWILNRYLSYTLNPDYIRKQDTTSTIISIASNVAGHPLVWDFVRSNWKKLFENYGGGSFSFANLIQGVTRRFSSEFELQQLEQFKADNSATGFGTGTRALEQALEKTRANIDWVKENKDAVFKWFTENSS

ANPEP

Aminopeptidase N

966 amino acids

Broad specificity aminopeptidase which plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Also involved in the processing of various peptides including peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. May also be involved the cleavage of peptides bound to major histocompatibility complex class II molecules of antigen presenting cells. May have a role in angiogenesis and promote cholesterol crystallization.

Belongs to the peptidase M1 family.

109.318 kDa

MAKGFYISKSLGILGILLGVAALCTIVALSVVYRQEKNKNTSQSPSMAPLNPTATSSPATTLDQNLPWNRYRLPKTLIPDSYNVVLRPYLSPNSQGLYIFTGSSTVRFTCQEATNVIIIHSKKLNYTITQGHRVVLRGVRGSQPPAIASTELVELTEYLVVHLQGQLVAGSQYEMDTQFQGELADDLAGFYRSEYMEGNVRKVVATTQMQAADARKSFPCFDEPAMKATFNITPIHPRDYTALSNMLPRSSTALPEDPNWTVTEFHTTPKMSTYLLAYIVSEFTNIEAQSPNNVQIRIWARPSAISEGHGQYALNVTGPILNFFANHYNTPYPLEKSDQIGLPDFNAGAMENWGLVTYRESALLFDPLVSSISNKERVVTVVAHELAHQWFGNLVTVDWWNDLWLNEGFASYVEYLGADYAEPTWNLKDLIVLNELHSVMAVDALASSHPLSSPADEVNTPAQISELFDSITYSKGASVLRMLSSFLTEDLFKEGLASYLHTFAYQNTIYLDLWEHLQQAVNSQSAIQLPASVRDIMDRWILQMGFPVVTVNTTNGIISQHHFLLDPTSNVTRPSDFNYLWIVPVSSMRNGVLEQEFWLEGVEQTQNSLFRVEGDNNWILANLNVTGYYQVNYDEGNWKKLQTQLQTNPSVIPVINRAQIIHDAFNLASAQKVPVTLALDNTLFLIRETEYMPWQAALSSLNYFKLMFDRSEVYGPMKNYLSKQVRPLFEHFKNITNDWTRRPDTLMDQYNEINAISTACSNGIQECETLVSDLFKQWMDDPSNNPIHPNLRTTVYCNAIALGGEREWDFAWEQFRNATLVNEADKLRSALACSNEVWILNRYLSYTLNPDYIRRQDATSTINSIASNVIGQTLVWDFVQSNWKKLFEDFGGGSFSFANLIRAVTRRFSTEYELQQLEQFRLNNLDTGFGSGTRALEQALEQTRANIKWVQENKEAVLAWFTANSA

Anpep

Aminopeptidase N

965 amino acids

Broad specificity aminopeptidase which plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Also involved in the processing of various peptides including peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. May also be involved the cleavage of peptides bound to major histocompatibility complex class II molecules of antigen presenting cells. May have a role in angiogenesis and promote cholesterol crystallization.

Belongs to the peptidase M1 family.

109.449 kDa

MAKGFYISKTLGILGILLGVAAVCTIIALSVVYAQEKNRNAENSAIAPTLPGSTSATTSTTNPAIDESKPWNQYRLPKTLIPDSYQVTLRPYLTPNEQGLYIFKGSSTVRFTCNETTNVIIIHSKKLNYTNKGNHRVALRALGDTPAPNIDTTELVERTEYLVVHLQGSLVKGHQYEMDSEFQGELADDLAGFYRSEYMEGGNKKVVATTQMQAADARKSFPCFDEPAMKASFNITLIHPNNLTALSNMLPKDSRTLQEDPSWNVTEFHPTPKMSTYLLAYIVSEFKYVEAVSPNRVQIRIWARPSAIDEGHGDYALQVTGPILNFFAQHYNTAYPLEKSDQIALPDFNAGAMENWGLVTYRESALVFDPQSSSISNKERVVTVIAHELAHQWFGNLVTVDWWNDLWLNEGFASYVEFLGADYAEPTWNLKDLIVLNDVYRVMAVDALASSHPLSSPANEVNTPAQISELFDSITYSKGASVLRMLSSFLTEDLFKKGLSSYLHTFQYSNTIYLDLWEHLQQAVDSQTAIKLPASVSTIMDRWILQMGFPVITVNTSTGEIYQEHFLLDPTSKPTRPSDFNYLWIVPIPYLKNGKEDHYWLETEKNQSAEFQTSSNEWLLLNINVTGYYQVNYDENNWRKIQNQLQTDLSVIPVINRAQIIHDSFNLASAGKLSITLPLSNTLFLASETEYMPWEAALSSLNYFKLMFDRSEVYGPMKRYLKKQVTPLFAYFKIKTNNWLDRPPTLMEQYNEINAISTACSSGLEECRDLVVGLYSQWMNNSDNNPIHPNLRSTVYCNAIAFGGEEEWNFAWEQFRKATLVNEADKLRSALACSNEVWILNRYLSYTLNPDYIRKQDATSTIVSIANNVVGQTLVWDFVRSNWKKLFEDYGGGSFSFANLIQGVTRRFSSEFELQQLEQFKEDNSATGFGSGTRALEQALEKTKANIKWVKENKDVVLKWFTENS

ANPEP

Aminopeptidase N

965 amino acids

Broad specificity aminopeptidase which plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Also involved in the processing of various peptides including peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. May also be involved the cleavage of peptides bound to major histocompatibility complex class II molecules of antigen presenting cells. May have a role in angiogenesis and promote cholesterol crystallization.

Belongs to the peptidase M1 family.

109.276 kDa

MAKGFYISKALGILAILLGVAAVATIIALSVVYAQEKNKNAERGTAAPTSPTGPTTTSATTLDQSKPWNRYRLPTTLLPDSYRVTLRPYLTPNNNGLYIFTGSSTVRFTCKEPTDVIIIHSKKLNYTQHSGHLAALKGVGDTQAPEIDRTELVLLTEYLVVHLKSSLEAGKTYEMETTFQGELADDLAGFYRSEYMDGNVKKVLATTQMQSTDARKSFPCFDEPAMKATFNITLIHPKDLTALSNMPPKGPSVPFDGDSNWSVTEFETTPVMSTYLLAYIVSEFTSVESVAPNDVQIRIWARPKATADNHGLYALNVTGPILNFFANHYNTAYPLPKSDQIALPDFNAGAMENWGLVTYRENALLYDPQSSSSSNKERVVTVIAHELAHQWFGNLVTLAWWNDLWLNEGFASYVEYLGADYAEPTWNLKDLMVPNDVYSVMAVDALVTSHPLTTPANEVNTPAQISEMFDTISYSKGASVIRMLSNFLTEDLFKKGLASYLQTFAYQNTTYLNLWEHLQMAVENQLSIRLPDTVSAIMDRWTLQMGFPVITVDTNTGTISQKHFLLDPNSTVTRPSQFNYLWIVPISSIRNGQPQEHYWLRGEERNQNELFKAAADDWVLLNINVTGYYQVNYDENNWKKIQNQLMSRRENIPVINRAQVIYDSFNLASAHMVPVTLALNNTLFLKNEMEYMPWQAAVSSLNYFKLMFDRTEVYGPMQNYLKNQVEPIFLYFENLTKNWTEIPENLMDQYSEINAISTACSNGLPKCEELAKTLFNQWMNNPNVNPIDPNLRSTIYCNAIAQGGQEEWDFAWNQLQQAELVNEADKLRSALACTNHVWLLNRYLSYTLNPDLIRKQDATSTITSIASNVIGQSLAWDFIRSNWKKLFEDYGGGSFSFSNLIQGVTRRFSTEFELQQLEEFKENNMDVGFGSGTRALEQALEKTKANINWVKENKEVVLNWFKDHS

ANPEP

Aminopeptidase N

963 amino acids

(Microbial infection) In case of porcine transmissible gastroenteritis coronavirus (TGEV) and porcine respiratory coronavirus (PRCoV) infections, serves as a receptor for TGEV and PRCoV spike glycoprotein in a species-specific manner.

Belongs to the peptidase M1 family.

108.832 kDa

MAKGFYISKALGILGILLGVAAVATIIALSVVYAQEKNKNAEHVPQAPTSPTITTTAAITLDQSKPWNRYRLPTTLLPDSYNVTLRPYLTPNADGLYIFKGKSIVRLLCQEPTDVIIIHSKKLNYTTQGHMVVLRGVGDSQVPEIDRTELVELTEYLVVHLKGSLQPGHMYEMESEFQGELADDLAGFYRSEYMEGNVKKVLATTQMQSTDARKSFPCFDEPAMKATFNITLIHPNNLTALSNMPPKGSSTPLAEDPNWSVTEFETTPVMSTYLLAYIVSEFQSVNETAQNGVLIRIWARPNAIAEGHGMYALNVTGPILNFFANHYNTSYPLPKSDQIALPDFNAGAMENWGLVTYRENALLFDPQSSSISNKERVVTVIAHELAHQWFGNLVTLAWWNDLWLNEGFASYVEYLGADHAEPTWNLKDLIVPGDVYRVMAVDALASSHPLTTPAEEVNTPAQISEMFDSISYSKGASVIRMLSNFLTEDLFKEGLASYLHAFAYQNTTYLDLWEHLQKAVDAQTSIRLPDTVRAIMDRWTLQMGFPVITVDTKTGNISQKHFLLDSESNVTRSSAFDYLWIVPISSIKNGVMQDHYWLRDVSQAQNDLFKTASDDWVLLNVNVTGYFQVNYDEDNWRMIQHQLQTNLSVIPVINRAQVIYDSFNLATAHMVPVTLALDNTLFLNGEKEYMPWQAALSSLSYFSLMFDRSEVYGPMKKYLRKQVEPLFQHFETLTKNWTERPENLMDQYSEINAISTACSNGLPQCENLAKTLFDQWMSDPENNPIHPNLRSTIYCNAIAQGGQDQWDFAWGQLQQAQLVNEADKLRSALACSNEVWLLNRYLGYTLNPDLIRKQDATSTINSIASNVIGQPLAWDFVQSNWKKLFQDYGGGSFSFSNLIQGVTRRFSSEFELQQLEQFKKNNMDVGFGSGTRALEQALEKTKANIKWVKENKEVVLNWFIEHS