ALA1

Phospholipid-transporting ATPase 1

1158 amino acids

Involved in transport of phospholipids. Contributes to transmembrane flipping of lipids. Has activity with phosphatidylserine and with a much lower efficiency with phosphatidylethanolamine, but not with phosphatidylcholine.

Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.

130.329 kDa

MDPRKSIDKPPHHDPILGVSSRWSVSSKDNKEVTFGDLGSKRIRHGSAGADSEMLSMSQKEIKDEDARLIYINDPDRTNERFEFTGNSIKTAKYSVFTFLPRNLFEQFHRVAYIYFLVIAVLNQLPQLAVFGRGASIMPLAFVLLVSAIKDAYEDFRRHRSDRVENNRLALVFEDHQFREKKWKHIRVGEVIKVQSNQTLPCDMVLLATSDPTGVVYVQTTNLDGESNLKTRYAKQETLLKAADMESFNGFIKCEKPNRNIYGFQANMEIDGRRLSLGPSNIILRGCELKNTAWALGVVVYAGGETKAMLNNSGAPSKRSRLETRMNLEIILLSLFLIVLCTIAAATAAVWLRTHRDDLDTILFYRRKDYSERPGGKNYKYYGWGWEIFFTFFMAVIVYQIMIPISLYISMELVRIGQAYFMTNDDQMYDESSDSSFQCRALNINEDLGQIKYLFSDKTGTLTDNKMEFQCACIEGVDYSDREPADSEHPGYSIEVDGIILKPKMRVRVDPVLLQLTKTGKATEEAKRANEFFLSLAACNTIVPIVSNTSDPNVKLVDYQGESPDEQALVYAAAAYGFLLIERTSGHIVINVRGETQRFNVLGLHEFDSDRKRMSVILGCPDMSVKLFVKGADSSMFGVMDESYGGVIHETKIQLHAYSSDGLRTLVVGMRELNDSEFEQWHSSFEAASTALIGRAGLLRKVAGNIETNLRIVGATAIEDKLQRGVPEAIESLRIAGIKVWVLTGDKQETAISIGFSSRLLTRNMRQIVINSNSLDSCRRSLEEANASIASNDESDNVALIIDGTSLIYVLDNDLEDVLFQVACKCSAILCCRVAPFQKAGIVALVKNRTSDMTLAIGDGANDVSMIQMADVGVGISGQEGRQAVMASDFAMGQFRFLVPLLLVHGHWNYQRMGYMILYNFYRNAVFVLILFWYVLFTCYTLTTAITEWSSVLYSVIYTAIPTIIIGILDKDLGRQTLLDHPQLYGVGQRAEGYSTTLFWYTMIDTIWQSAAIFFIPMFAYWGSTIDTSSLGDLWTIAAVVVVNLHLAMDVIRWNWITHAAIWGSIVAACICVIVIDVIPTLPGYWAIFQVGKTWMFWFCLLAIVVTSLLPRFAIKFLVEYYRPSDVRIAREAEKLGTFRESQPVGVEMNLIQDPPRR

ALA1

Alanine--tRNA ligase, mitochondrial

983 amino acids

Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.

Belongs to the class-II aminoacyl-tRNA synthetase family.

110.059 kDa

MTSTTGLRNLTLSFKKQLTTSTRTIMTIGDKQKWTATNVRNTFLDYFKSKEHKFVKSSPVVPFDDPTLLFANAGMNQYKPIFLGTVDPASDFYTLKRAYNSQKCIRAGGKHNDLEDVGKDSYHHTFFEMLGNWSFGDYFKKEAITYSWTLLTEVYGIPKDRLYVTYFEGDEKLGLEPDTEARELWKNVGVPDDHILPGNAKDNFWEMGDQGPCGPCSEIHYDRIGGRNAASLVNMDDPDVLEVWNLVFIQFNREQDGSLKPLPAKHIDTGMGFERLVSVLQDVRSNYDTDVFTPLFERIQEITSVRPYSGNFGENDKDGIDTAYRVLADHVRTLTFALADGGVPNNEGRGYVLRRILRRGARYARKYMNYPIGNFFSTLAPTLISQVQDIFPELAKDPAFLFEILDEEEASFAKTLDRGERLFEKYASAASKTESKTLDGKQVWRLYDTYGFPVDLTELMAEEQGLKIDGPGFEKAKQESYEASKRGGKKDQSDLIKLNVHELSELNDAKVPKTNDEFKYGSANVEGTILKLHDGTNFVDEITEPGKKYGIILDKTCFYAEQGGQEYDTGKIVIDDAAEFNVENVQLYNGFVFHTGSLEEGKLSVGDKIIASFDELRRFPIKNNHTGTHILNFALKETLGNDVDQKGSLVAPEKLRFDFSHKKAVSNEELKKVEDICNEQIKENLQVFYKEIPLDLAKSIDGVRAVFGETYPDPVRVVSVGKPIEELLANPANEEWTKYSIEFCGGTHVNKTGDIKYFVILEESGIAKGIRRIVAVTGTEAFEAQRLAEQFAADLDAADKLPFSPIKEKKLKELGVKLGQLSISVITKNELKQKFNKIEKAVKDEVKSRAKKENKQTLDEVKTFFETNENAPYLVKFIDISPNAKAITEAINYMKSNDSVKDKSIYLLAGNDPEGRVAHGCYISNAALAKGIDGSALAKKVSSIIGGKAGGKGNVFQGMGDKPAAIKDAVDDLESLFKEKLSI

ALA1

Alanine--tRNA ligase

969 amino acids

Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.

Belongs to the class-II aminoacyl-tRNA synthetase family.

108.275 kDa

MIKTLLRRMSSNTTIPTPNGSNHWTASKVRSTFLDYFKKQQHTYVPSSSVVPHNDPTLLFANAGMNQYKPIFLGTVDPASDFASLKRAANSQKCIRAGGKHNDLEDVGRDSYHHTFFEMLGNWSFGDYFKKEAIDYSWELLTKVYGLQEDRLYVTYFGGDEKQGLEPDLEAKNFWLKVGVPEDHILPGSVEDNFWEMGDQGPCGPCSEIHYDRIGGRNASALVNMDDPNVLEVWNVVFIQYNREADGNLRTLPNKHIDTGMGFERLVSILQNKYSNYDTDVFLPIFDKIREITGVRPYTGKFGNEDKDGIDTAYRVIADHVRTLTFAICDGGVPNNEGRGYVLRRILRRGSRYVRKYMNYPIGGFFQQLVDVVIEQNKEIFPEISSGAQDLKEILNEEELSFAKTLDRGEKLFEQYAIIASKTPEQTLSGKDVWRLYDTYGFPVDLTRLMAEEAGLKIDEEGFERAKEESREASKGSGTKDGKTLVKLDVHALSELDQNDAIPKTNDEFKYGLENVKAKVVGIYDGSKFVDSIEDPSIQYGILLDKTPFYAEQGGQEYDTGKLVIDGKSEFNVANVQVYAGYVLHTGNIVDGKLNVGDEIIATYDELRRWPIRNNHTGTHILNFALREVLGDGVDQKGSLVAPEKLRFDFSHKQAVTAKELEKIEAISNKYIKNNDKVYYKDVSLTKAKEINGLRAVFGETYPDPVRVVSIGVSVDDLLADPTNTKWHEISIEFCGGTHVAKTGDIKDLVIIEESGIAKGIRRIVAVTGHDAHHVQKVANEFEQEIDNASSLPFGVAKESKSKELGVALKKLSISVLDKQRLTEKFNKLDKSIKDNLKAKQKEETKKTLDVVNNWLNDKENASSFLVAHVPITANAKAITEAINLIKKQDKTKSIYLLTGETDKVAHGCYVSDEAIAKGINANELAKAVSENIGGKAGGKGNIVQGMGDKPQGINTAIEEVTKLFKEKL

ala1

Alanine--tRNA ligase

961 amino acids

Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.

Belongs to the class-II aminoacyl-tRNA synthetase family.

107.306 kDa

MASNLQSQPKWTSKLVRDTFLQYFQGKGHTFVASSPVAPLSDPTLLFTNAGMNQFKSIFLGTVNPNSDFAQLKSAVNSQKCIRAGGKHNDLDDVGKDSYHHTFFEMLGNWSFGDYFKKEAIQYSWELLTQVYGLDPGRLYVTYFEGNKEGGLQPDLEAKALWKAVGVPEDHILPGNMKDNFWEMGDQGPCGPCSEIHYDRIGGRNAASLVNQDDPNVLEIWNNVFIQYNRENDGSLRSLPNKHVDTGMGFERLVSVLQDKSSNYDTDVFGPIFQTIQVITGAREYQGRFGTDDSDGIDTAYRVVADHVRTLMFAISDGVVPNNEGRGYVIRRVLRRGARYARKYFNVEIGSFFSKIVPTVVEQLGDMFPELKQKQQDVIEILNEEEISFAKTLDRGERQFEQYAQQAKTAGDHKLHGADVWRLYDTFGFPVDLTRIMAEERGLEIDDRQFEEARHKAKEASKGQKKTTTGSVKLDVHDLGKLEKMNGVPKTDDSAKFEIGNVTAQIKAIYHGKTFHSSTQNLDDSEQIGIILDRTNFYAEQGGQENDTGRIVIDGQAELEVVDVQQYAGYVLHTGYMKYGSFKVDDTVICEYDELRRWPIRNNHTGTHILNFALRGVLGDGIEQKGSLVSAEKLRFDFSHKSPVTDVELVKIEDLSTQYIRRNCLVYSKEVPLSIARNIAGVRAVFGETYPDPVRVVSVGAELDEILKNVEDPRWADFSIEFCGGTHVQKTGDIKDLVILEESGIAKGIRRIIAVTGEDAHEVQRLAEEFEKRLNHLEAMPSGSAKEQNAKQIQVELNQLSISAVQKSRFRERFTQINKKIIDEQKAQQKLESKKAVESITSYFAAPENANKSWLIAKLPISANAKAVSECLTYVKTKLADKMVYVLASSLEDGRVAHGCYVPKAISDQGASASEWSSAVSRAVGGKAGGKGPTSIGNGINPEKVDDAVDLASEYLSKFKL

ala1

Alanine--tRNA ligase

959 amino acids

Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.

Belongs to the class-II aminoacyl-tRNA synthetase family.

107.377 kDa

MTAESEVVNWPANEIRRTFLKYFEDHGHTIVPSSSVIPYDDPTLLFANAGMNQFKPIFLGTVDPSSDFAKLKRACDSQKCIRAGGKHNDLEDVGKDNYHHTMFEMLGNWSFGDYFKKEAIAMAWDLLTNVYGLKKDQLYVTYFGGHEESGLEPDLEARQLWLDIGIDESRVIPGSLKDNFWEMGDQGPCGPCSEIHYDRIGNRTVPELVNMDDPNVLEIWNIVFIQFNREKDGSLRPLPNRHVDTGMGFERLVSVIQNKTSNYDTDVFSPIFAKIQELTNARPYTGKMGDEDVDGIDTAYRVVADHVRTLTFAISDGGVPNNEGRGYVLRRILRRGARYVRKKFGVPIGNFFSRLSLTVVEQMGDFFPELKRKVDDVRELLDEEEESFSRTLDRGEKMFEQYAAAAKKTPSKTLQGNDVWRLYETYGFPVDLTHLMAEEAGIKIDEPGFEAAQARSKEISKQASKGGSSGDDLLVLDVHALGALSKMDDIPETDDVFKHNSVSLKSVIKGIYHKGGFQKSTEGFNSGEQLGLLLDRTNFYAEQGGQEYDTGHIVIDGVADFRVTNVQVYAGYVLHTGFLEYGNLTVNDSVVCEYDEIRRWHLMNNHTVTHILNLALRNTLGDGIDQRGSLVSQEKLRFDFSYKSSIPIDKLLLVENYCNNVIQDNLSVYSKEVALSKAKEINGLRAVFGEVYPDPVRVVCIGVDIDTLLQEPKKPDWTKYSIEFCGGTHCDKSGEIKDFVILEENGIAKGIRRIVAVTSTEANRVSRLANEFDARIAKLEKMPFSPAKEAELKKISVDLSKLVVAAVRKHAMKERIAKITKQVQEHVKAINAAEQKEVVNVVTEYFKENPDMSFVVAKVPISANPKALSFALTYAKKNLKDKSIYLLASDDTKVAHACLVSPEAMKKLTPQEWSQKVCHSIGGRSGGKGDTCQGVGDKPLSIDVAVEEAIEFFQGKLTI