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AIMP2

Gene
AIMP2
Protein
Probable aminoacyl tRNA synthase complex-interacting multifunctional protein 2
Organism
Drosophila melanogaster
Length
334 amino acids
Function
Required for assembly and stability of the aminoacyl-tRNA synthase complex.
Mass
36.934 kDa
Sequence
MYELKTLLPQFDIKLPTCMYPLKNVSLAADSLASGSSTSASTSASTSSCKLEANRIDRTGRNAATCALDLDSLGRQIQRLLKDDTASVAARQEKVLKQLEELKAQLGQIRAGLGVCGKTFQHTTAFQNGGLKEVPLQDVVINGHPNFIPYALLALKNAWRNLYTIDVKTFTHSTMADIGPAAREFEANLAKVPVNPALPKISVTLIWKNCEHTEMISSPTMYVPIYGEVNIIRYLGRVGPAEYRYEGSPLCNEIDLVLDICYQLLRCNTHKTQVAMVRLLDKRLQKQQYFGGSQMSVADVGVYSSLIRMPAVTEKDLTPALVAWRKRAKLVVQI

Gene
AIMP2
Protein
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2
Organism
Homo sapiens
Length
320 amino acids
Function
Required for assembly and stability of the aminoacyl-tRNA synthase complex (PubMed:19131329). Mediates ubiquitination and degradation of FUBP1, a transcriptional activator of MYC, leading to MYC down-regulation which is required for aveolar type II cell differentiation. Blocks MDM2-mediated ubiquitination and degradation of p53/TP53. Functions as a proapoptotic factor.
Mass
35.349 kDa
Sequence
MPMYQVKPYHGGGAPLRVELPTCMYRLPNVHGRSYGPAPGAGHVQEESNLSLQALESRQDDILKRLYELKAAVDGLSKMIQTPDADLDVTNIIQADEPTTLTTNALDLNSVLGKDYGALKDIVINANPASPPLSLLVLHRLLCEHFRVLSTVHTHSSVKSVPENLLKCFGEQNKKQPRQDYQLGFTLIWKNVPKTQMKFSIQTMCPIEGEGNIARFLFSLFGQKHNAVNATLIDSWVDIAIFQLKEGSSKEKAAVFRSMNSALGKSPWLAGNELTVADVVLWSVLQQIGGCSVTVPANVQRWMRSCENLAPFNTALKLLK

Gene
Aimp2
Protein
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2
Organism
Mus musculus
Length
320 amino acids
Function
Required for assembly and stability of the aminoacyl-tRNA synthase complex (PubMed:12060739). Mediates ubiquitination and degradation of FUBP1, a transcriptional activator of MYC, leading to MYC down-regulation which is required for aveolar type II cell differentiation (PubMed:12819782). Blocks MDM2-mediated ubiquitination and degradation of p53/TP53 (PubMed:18695251). Functions as a proapoptotic factor (PubMed:16135753).
Mass
35.378 kDa
Sequence
MPMYQVKPYHGGSAPLHVELPTCMYRLPNVHSKTTSPATDAGHVQETSEPSLQALESRQDDILKRLYELKAAVDGLSKMIHTPDADLDVTNILQADEPTTLATNTLDLNSVLGKDYGALKDIVINANPASPPLSLLVLHRLLCERYRVLSTVHTHSSVKNVPENLVKCFGEQARKQSRHEYQLGFTLIWKNVPKTQMKFSVQTMCPIEGEGNIARFLFSLFGQKHNAVTLTLIDSWVDIAMFQLREGSSKEKAAVFRSMNSALGRSPWLVGNELTVADVVLWSVLQQTGGSSGAAPTNVQRWLKSCENLAPFSTALQLLK

Gene
Aimp2
Protein
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2
Organism
Rattus norvegicus
Length
320 amino acids
Function
Required for assembly and stability of the aminoacyl-tRNA synthase complex. Mediates ubiquitination and degradation of FUBP1, a transcriptional activator of MYC, leading to MYC down-regulation which is required for aveolar type II cell differentiation. Blocks MDM2-mediated ubiquitination and degradation of p53/TP53. Functions as a proapoptotic factor.
Mass
35.443 kDa
Sequence
MPMYQVKPYHGGSAPLRVELPTCMYRLPNVHSKTTSPATDAGHVQEPSEPSLRALESRQDDILKRLYELKAAVDGLSKMIHTPDADLDVTNILQADEPTTLTTNALDLNSVLGKDYGALKDIVINANPASPPLSLLVLHRLLCERYRVLSTVHTHSSVKNVPENLLKCFGEQARKQSRHEYQLGFTLIWKNVPKTQMKFSVQTMCPIEGEGNIARFLFSLFGQKHNAVHLTLIDSWVDIAMFQLREGSSKEKAAVFRSMNSALGKSPWLVGNELTVADVVLWSVLQQTGGSSGAAPTNVQRWLKSCENLAPFSTALQLLK

Gene
AIMP2
Protein
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2
Organism
Bos taurus
Length
320 amino acids
Function
Required for assembly and stability of the aminoacyl-tRNA synthase complex. Mediates ubiquitination and degradation of FUBP1, a transcriptional activator of MYC, leading to MYC down-regulation which is required for aveolar type II cell differentiation. Blocks MDM2-mediated ubiquitination and degradation of p53/TP53. Functions as a proapoptotic factor.
Mass
35.178 kDa
Sequence
MPMYQVKPYHEGSGSLRVELPTCMYRLPNVHGRTGSPAPSADHVQEASDPSLQALESHQDDILKRLYELKAAVDGLSKMIQTPDADLDVTNIIQADEPAALSTSTVDLNAMLGQDHGALKDIVINANPASPPLSLLVLHRLLCDHYKVLSSVHTHSAVRSVPANLLQCFGEQTRQQPRHEYQLGFTLIWKDVPKTQMKFSVQTMCPIEGEGNIARFLFSLFGQKQDAVNLTLIDSWVDIAIFQLKEGSSKEKAAVFRSMNSALGKTPWLVGDELTVADVVLWSVLRQTGGCGGMAPANVQKWMQACENLAPFHTALKLLQ

Gene
AIMP2
Protein
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2
Organism
Cricetulus griseus
Length
320 amino acids
Function
Required for assembly and stability of the aminoacyl-tRNA synthase complex. Mediates ubiquitination and degradation of FUBP1, a transcriptional activator of MYC, leading to MYC down-regulation which is required for aveolar type II cell differentiation. Blocks MDM2-mediated ubiquitination and degradation of p53/TP53. Functions as a proapoptotic factor.
Mass
35.433 kDa
Sequence
MPMYQVKSYHGGSAPLRVELPTCMYRLPNVHSKTTSPATDAGHVQETSEPSLQALESRQDDILKRLYELKAAVDGLSKMIHTPDADLDVTNILQADEPVPLTTNALDLNLVLGKDYGALKDIVINANPASPPISLLVLHRLLCERYRVLSTVHTHSSVKNVPENLLKCFGEQARKQSRHEYQLGFTLIWKNVPKTQMKFSVQTMCPIEGEGNIARFLFSLFGQKHSAVNLTLIDSWVDIAMFQLKEGSSKERAAVFRSMNSALGKSPWLVGNELTVADVVLWSVLQQTGDGSGVAPANVQRWLKSCENLVPFSTALQLLK