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AGBL5

Gene
agbl5
Protein
Cytosolic carboxypeptidase-like protein 5
Organism
Xenopus tropicalis
Length
944 amino acids
Function
Metallocarboxypeptidase that mediates tubulin deglutamylation. Specifically catalyzes the deglutamylation of the branching point glutamate side chains generated by post-translational glutamylation in proteins such as tubulins. In contrast, it is not able to act as a long-chain deglutamylase that shortens long polyglutamate chains.
Similarity
Belongs to the peptidase M14 family.
Mass
105.6 kDa
Sequence
MEVRCGGLLFSSKFDSGNLARVEKVEKPGAEGDAFSGSVSGGSVPTPDYEFNIWTKPDCAETEYENGNRSWFYFSVRFGAPGKLIKINIMNMNKQSKLYSQGMAPFVRTVPIRSRWERIRDRPTFEMVENQFILSFVHRFLDCRGSTTYFAFCFPFSYEESQELMAGLDDRFSDCKNITPGSFPDSIYYHRELLCHSLDGLRVDLLTISSCHGMTEEREPRLDKLFPDRSTPRPYRFTGKRVYFLSSRVHPGETPSSFVFNGFLEFILRQDDPRAQMLRRMFVFKLIPMLNPDGVVRGHYRTDSRGVNLNRQYLNPDFELHPSVYAAKTVLLYHHVYNSVGPNDPDWRTSVSLQTSNISLCPKTSNHSLKDLPLEDSLSELEKANNLLNSMEKEECYITCPQAVTQGAPPENDPNFLSDSRDFIRQRDVFILESDTEPKDIYSHSGSSQPTIFTKSIPPQESGIAFYVDLHGHASKRGCFMYGNYFTEENDQVENMLYPKLISLNSANFDFLACNFSEKNMYAKDKRDGQSKEGSGRVAIHKATGIIHSYTLECNYNTGRCVNSIPAACHDCGRASPPPPPAFPPKYTTQVFEQIGRAVATAALDMAECNPWPRLIMSEYNNLTNLRAWMLKHLRNTKGVLPGTLKKKSTKSPVKASSLTSGSLSENSLIRTRSYSNSTASTNSQQNSPQIKPSINFTFLCSSSNHSPPKVSQRVLGPVRETKAQEKRRQQSLLRSSVRSPTACQQRLSTQAPSLSSGYPKTSSHAKTSCPLSLSLSMSGSGFSGLSQAAKVKNGTKKNNLEGDSTRQHIHQGHGIALLQNMQKRGSSHNNAEYSKSLESLGVRPSRIPVRRNGLLTNEKESPILRVWKYTTDTSLKHCSLADLAAVTSSLTVCSVPLLKSKAEEPVFICEATKETADQHFPAVSQDAAHLSAYQSVLSFCSEA

Gene
AGBL5
Protein
Cytosolic carboxypeptidase-like protein 5
Organism
Homo sapiens
Length
886 amino acids
Function
Metallocarboxypeptidase that mediates protein deglutamylation. Specifically catalyzes the deglutamylation of the branching point glutamate side chains generated by post-translational glutamylation in proteins such as tubulins. In contrast, it is not able to act as a long-chain deglutamylase that shortens long polyglutamate chains, a process catalyzed by AGTPBP1/CCP1, AGBL2/CCP2, AGBL3/CCP3, AGBL1/CCP4 and AGBL4/CCP6. Mediates deglutamylation of CGAS, regulating the antiviral activity of CGAS.
Similarity
Belongs to the peptidase M14 family.
Mass
97.534 kDa
Sequence
MELRCGGLLFSSRFDSGNLAHVEKVESLSSDGEGVGGGASALTSGIASSPDYEFNVWTRPDCAETEFENGNRSWFYFSVRGGMPGKLIKINIMNMNKQSKLYSQGMAPFVRTLPTRPRWERIRDRPTFEMTETQFVLSFVHRFVEGRGATTFFAFCYPFSYSDCQELLNQLDQRFPENHPTHSSPLDTIYYHRELLCYSLDGLRVDLLTITSCHGLREDREPRLEQLFPDTSTPRPFRFAGKRIFFLSSRVHPGETPSSFVFNGFLDFILRPDDPRAQTLRRLFVFKLIPMLNPDGVVRGHYRTDSRGVNLNRQYLKPDAVLHPAIYGAKAVLLYHHVHSRLNSQSSSEHQPSSCLPPDAPVSDLEKANNLQNEAQCGHSADRHNAEAWKQTEPAEQKLNSVWIMPQQSAGLEESAPDTIPPKESGVAYYVDLHGHASKRGCFMYGNSFSDESTQVENMLYPKLISLNSAHFDFQGCNFSEKNMYARDRRDGQSKEGSGRVAIYKASGIIHSYTLECNYNTGRSVNSIPAACHDNGRASPPPPPAFPSRYTVELFEQVGRAMAIAALDMAECNPWPRIVLSEHSSLTNLRAWMLKHVRNSRGLSSTLNVGVNKKRGLRTPPKSHNGLPVSCSENTLSRARSFSTGTSAGGSSSSQQNSPQMKNSPSFPFHGSRPAGLPGLGSSTQKVTHRVLGPVREPRSQDRRRQQQPLNHRPAGSLAPSPAPTSSGPASSHKLGSCLLPDSFNIPGSSCSLLSSGDKPEAVMVIGKGLLGTGARMPCIKTRLQARPRLGRGSPPTRRGMKGSSGPTSPTPRTRESSELELGSCSATPGLPQARPPRPRSAPAFSPISCSLSDSPSWNCYSRGPLGQPEVCFVPKSPPLTVSPRV

Gene
Agbl5
Protein
Cytosolic carboxypeptidase-like protein 5
Organism
Mus musculus
Length
886 amino acids
Function
Metallocarboxypeptidase that mediates protein deglutamylation. Specifically catalyzes the deglutamylation of the branching point glutamate side chains generated by post-translational glutamylation in proteins such as tubulins (PubMed:20519502, PubMed:21074048). In contrast, it is not able to act as a long-chain deglutamylase that shortens long polyglutamate chains, a process catalyzed by AGTPBP1/CCP1, AGBL2/CCP2, AGBL3/CCP3, AGBL1/CCP4 and AGBL4/CCP6 (PubMed:25103237). Mediates deglutamylation of CGAS, regulating the antiviral activity of CGAS (PubMed:26829768).
Similarity
Belongs to the peptidase M14 family.
Mass
97.607 kDa
Sequence
MELRCGGLLFSSRFDSGNLAHVEKVETVSSDGEGVGGVATAPASGSAASPDYEFNVWTRPDCAETEYENGNRSWFYFSVRGGTPGKLIKINIMNMNKQSKLYSQGMAPFVRTLPSRPRWERIRERPTFEMTETQFVLSFVHRFVEGRGATTFFAFCYPFSYSDCQDLLSQLDQRFSENYSTHSSPLDSIYYHRELLCYSLDGLRVDLLTITSCHGLRDDREPRLEQLFPDLGTPRPFRFTGKRIFFLSSRVHPGETPSSFVFNGFLDFILRPDDPRAQTLRRLFVFKLIPMLNPDGVVRGHYRTDSRGVNLNRQYLKPDAVLHPAIYGAKAVLLYHHVHSRLNAKSPTNQQPTLHLPPEAPLSDLEKANNLHNEAHLGQSPDGENPATWPETEPAEEKTDPVWLMPQPIPELEEPAPDTIPPKESGVAYYVDLHGHASKRGCFMYGNSFSDESTQVENMLYPKLISLNSAHFDFQGCNFSEKNMYARDRRDGQSKEGSGRVAIYKASGIIHSYTLECNYNTGRSVNSIPAACHDNGRASPPPPPAFPSRYTVELFEQVGRAMAIAALDMAECNPWPRIVLSEHSSLTNLRAWMLRHVRNSRGLTSAGNMGASKKRGARTPPKSNNSLPVSCSENALSRVRSFSTGTSTGGSSSSQQNSPQMKNSPSFPFHGSRTAGLPGLGSSTQKVSHRVLGPVREPRCSDRRRRQQPLNHRSTTSSLAPSPTLASSGPTSSRNMGSCLLPNSLSLSGSSCSFSSSGDKPEAVMVIGKSLLGAGARIPCIRTRLQARPRLGRSSPPTRRGMRGSSPTSPIPQTRESSELEPGPHSATPGLPQAGPPRPRSAPAFSPISCTLSDSPSRICYSRGLLNQCEVCFVPKSPPLTISPRV

Gene
AGBL5
Protein
Cytosolic carboxypeptidase-like protein 5
Organism
Bos taurus
Length
885 amino acids
Function
Metallocarboxypeptidase that mediates protein deglutamylation. Specifically catalyzes the deglutamylation of the branching point glutamate side chains generated by post-translational glutamylation in proteins such as tubulins. In contrast, it is not able to act as a long-chain deglutamylase that shortens long polyglutamate chains, a process catalyzed by AGTPBP1/CCP1, AGBL2/CCP2, AGBL3/CCP3, AGBL1/CCP4 and AGBL4/CCP6. Mediates deglutamylation of CGAS, regulating the antiviral activity of CGAS.
Similarity
Belongs to the peptidase M14 family.
Mass
97.441 kDa
Sequence
MELRCGGLLFSSRFDSGNLAHVEKVESVSNDGEGVAGGASASTSSIASSPDYEFNVWTRPDCAETEFENGNRSWFYFSVRGGTPGKLIKINIMNMNKQSKLYSQGMAPFVRTLPTRPRWERIRDRPTFEMTETQFVLSFIHRFVEGRGATTFFAFCYPFSYSDCQDLLSQLDQRFLENSPTHSSPLDTIYYHRETLCYSLDGLRVDLLTISSCHGLREDREPRLEQLFPDASTPRPFRFTGKRIFFLSSRVHPGETPSSFVFNGFLDFILRPDDPRAQTLRRLFVFKLIPMLNPDGVVRGHYRTDSRGVNLNRQYLKPDAVLHPAIYGAKAVLLYHHVHSRLNSQSPSEHQHSSHLPPDAPLSDPEKADSLQNRAHLGRSSSGDKPEAWTQTEVAEQKPNSVWITPQESAEVEQLAPDAIPPRESGVAYYVDLHGHASKRGCFMYGNSFSDENTQVENMLYPKLISLNSAHFDFQGCNFSEKNMYARDRRDGQSKEGSGRVAIYKASGIIHSYTLECNYNTGRSVNSIPAACHDNGRASPPPPPAFPSRYTVELFEQVGRAMAIAALDMAECNPWPRIVLSEHSSLTNLRAWMLKHVRSSRGLSTTVNMSISKKRGSRTPPRSNNGLPVSCSENTLSRARSFSTGTSAGGSSSSQQNSPQMKNSPSFPFHGSRPAGLPGLGSSTQKVSHRVLGPVREPRSQDRRRRQQPVTHRPTSSSLAPSPTPASSNLASSHMGSCLLPNSLSISGSSCSFLSSGDKTEAVMVIGKGLLGAGPRIPCIRTRLQARPRLAQGSPPTRRGMRGSPGPTSPIPQTKKSSEPELGPRCTPRLPQAGPPRPCSAPAFSPISCSLSDSQSRICYSGGPLGQTEVCFVPKSPPFTVSPRV

Gene
agbl5
Protein
Cytosolic carboxypeptidase-like protein 5
Organism
Danio rerio
Length
885 amino acids
Function
Metallocarboxypeptidase that mediates tubulin deglutamylation. Specifically catalyzes the deglutamylation of the branching point glutamate side chains generated by post-translational glutamylation in proteins such as tubulins. In contrast, it is not able to act as a long-chain deglutamylase that shortens long polyglutamate chains.
Similarity
Belongs to the peptidase M14 family.
Mass
98.709 kDa
Sequence
MEIRVGSAVFSSRFDSGNLARVERVEASEAAGESSRSASVPQPDYEFNVWTRPDCASTEFENGNRSWFYFSVRGLLPGKLLKINMMNMNKQSKLYTQGMAPFVRTLPVKTRWERVRDRPTFEMSDSQFILSFVHRLLDVRGVTTYFSFCYPFSYAECQDMMLQLDHKFLSSTSTHTACSPPESIYYHRELLCHSLDGHRVDLITVSSCHGLLEEREPRLDKLFPDLSTARSHRFTGKRVFFVSSRVHPGETPSSFVFNGFLNFILSQEDPRAQTLRRMFVFKLIPMLNPDGVVRGHYRTDSRGVNLNRQYVNPSPDLHPSIYGAKSLLLYHHIHNRLGHASGSALKTSNQSNTSPPVATPTERERCMNLRNEAERGEGPTFDLSEIPMQLEESWEKSGVQREAEHSDENESAQSRGETNSAPSEQVPPQESGVAYYIDLHGHASKRGCFMYGNNLTEESQQVENMLYAKLISLNCAHFDFLGCNFSEKNMYARDKRDGQSKEGSGRVAIHKAIGLVHSYTLECNYNTGRSVNTIPPACHDNGRATPPPPPAFPPKYTPEVYEQVGRAVAVAALDMAECNPWPRLVLSEHSSLLNLRASILKHVRNSTGLTSNNRRNTHCKTSSSPPKPVSLSTSASENSLNRTRSTTNVQGSRQTPQLKSSPSFTFGTTAHRPSHRSLGPVRECKAQEKRRPPPPPLPHHHHQQHQRLSVRLSAPVRAPLSPSSSSSSSSSSPSSSSSAPGPGSISLAGNSCPEFRPANQIKELRGGRGKGGRSGPAYCHSSQQRTALTTKEPLQDSLDILTSIEYSRCELQPRPSRIPVRRELQSSVIPLSSTETPTMRVWKLIKPGLKKHLAGVSGKDRLSTKALLKNSSRQTDQHIHRSLPT

Gene
AGBL5
Protein
Cytosolic carboxypeptidase-like protein 5
Organism
Ailuropoda melanoleuca
Length
884 amino acids
Function
Metallocarboxypeptidase that mediates protein deglutamylation. Specifically catalyzes the deglutamylation of the branching point glutamate side chains generated by post-translational glutamylation in proteins such as tubulins. In contrast, it is not able to act as a long-chain deglutamylase that shortens long polyglutamate chains, a process catalyzed by AGTPBP1/CCP1, AGBL2/CCP2, AGBL3/CCP3, AGBL1/CCP4 and AGBL4/CCP6. Mediates deglutamylation of CGAS, regulating the antiviral activity of CGAS.
Similarity
Belongs to the peptidase M14 family.
Mass
96.914 kDa
Sequence
MELRCGGLLFSSRFDSGNLAHVEKVDSVSGDGEGGAAGASAPFSSIASSPDYEFNVWTRPDCAETEFENGNRSWFYFSVRGGTPGKLIKINIMNMNKQSKLYSQGMAPFVRTLPTRPRWERIRDRPTFEMTETQFVLSFVHRFVEGRGATTFFAFCYPFSYSDCQDLLNQLDQRFLENHPTHSSPLDTIYYHREILCYSLDGLRVDLLTITSCHGLREDREPRLQQLFPDTGTPRPFCFTGKRIFFLSSRVHPGETPSSFVFNGFLDFILRPDDPRAQTLRRLFVFKLIPMLNPDGVVRGHYRTDSRGVNLNRQYLKPDAALHPAIYGAKAVLLYHHVHSRLHPQSPSEHQHSPCLPPDAPLSDLEKANHLRNEAHLGHTSDGDSPEDWTQTRPAEQKASGVWLMPQQCADAEQPAPDTIPPKESGVAYYVDLHGHASKRGCFMYGNSFSDESTQVENMLYPKLISLNSAHFDFQGCNFSEKNMYARDRRDGQSKEGSGRVAIYKASGIIHSYTLECNYNTGRSVNSIPAACHDNGRASPPPPPAFPSRYTVELFEQVGRAMAIAALDMAECNPWPRIVLSEHSSLTNLRAWMLKHVRSSRGLSSTVSGAVNKKRGSRTPPRSNSGLPVSCSENPLSRARSFSTGTSAGGSSSSQQNSPQMKNSPSFPFHGSRPTGLPGLGSSTQKVSHRVLGPVREPRSQDRRRRQQPLTHRPTSSSLAPSPNPTSSSPASSHSTGPCLLPSAFSVSGSSCSLLSSGDKPEAVMVIGKGLLGPRIPCIRTRLQVRPRLGQGSPPTCRGMSGSSGPTSPIPRTRESSEPEPGPHSAPGLPQAGPPRPRSAPAFSPISCSLSDSQSRICYSGGPLGQPEVCFGPKSPPLTVSPRV

Gene
Agbl5
Protein
Cytosolic carboxypeptidase-like protein 5
Organism
Rattus norvegicus
Length
832 amino acids
Function
Metallocarboxypeptidase that mediates protein deglutamylation. Specifically catalyzes the deglutamylation of the branching point glutamate side chains generated by post-translational glutamylation in proteins such as tubulins. In contrast, it is not able to act as a long-chain deglutamylase that shortens long polyglutamate chains, a process catalyzed by AGTPBP1/CCP1, AGBL2/CCP2, AGBL3/CCP3, AGBL1/CCP4 and AGBL4/CCP6. Mediates deglutamylation of CGAS, regulating the antiviral activity of CGAS.
Similarity
Belongs to the peptidase M14 family.
Mass
92.554 kDa
Sequence
MELRCGGLLFSSRFDSGNLAHVEKVETVPSDGEGVGGAATAPTSGSASSPDYEFNVWTRPDCAETEYENGNRSWFYFSVRGGTPGKLIKINIMNMNKQSKLYSQGMAPFVRTLPSRPRWERIRERPTFEMTETQFVLSFVHRFVEGRGATTFFAFCYPFSYSDCQDLLSQLDQRFPENYSAHSSPLDSIYYHRELLCYSLDGLRVDLLTITSCHGLRDDREPRLEQLFPDVGTPRPFRFTGKRIFFLSSRVHPGETPSSFVFNGFLDFILRPDDPRAQTLRRLFVFKLIPMLNPDGVVRGHYRTDSRGVNLNRQYLKPDAVLHPAIYGAKAVLLYHHVHSRLNSKNPSNQQPSSLHLPPEVPLSDLEKANNLHNELHLGQSPDGENHDRWTETEPTEEKTDPVWIMPQPIPELEEPAPDAIPPKESGVAYYVDLHGHASKRGCFMYGNSFSDESTQVENMLYPKLISLNSAHFDFQGCNFSEKNMYARDRRDGQSKEGSGRVAIYKASGIIHSYTLECNYNTGRSVNSIPAACHDNGRASPPPPPTFPSRYTVELFEQVGRALAIAALDMAECNPWPRIVLSEHSSLTNLRAWMLKHVRNSRGLTSTANVGLNKKRGSRTPPKSNNGLPVSCSENALSRARSFSTGTSTGGSSSQQNSPQMKNSPSFPFHGSRPAGLPGLGSSTQKVSHRVLGPVREPRCPDRRRRQQQQQQQQQQQQQQQQQPLNQRSTTSSLAPSPTLASASPTSSRNMGSCLLPNSLSLSGSSCPFSSSGDKPEAVMVIGKSLLGAGARIPCIRTRLQTCQRRVSARRGPGFPRLGPGWAGAHRRLAEG