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AGBL2

Gene
agbl2
Protein
Cytosolic carboxypeptidase 2
Organism
Xenopus tropicalis
Length
967 amino acids
Function
Metallocarboxypeptidase that mediates deglutamylation of target proteins. Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation in proteins such as tubulins. Also removes gene-encoded polyglutamates from the carboxy-terminus of target proteins such as MYLK. Does not show detyrosinase or deglycylase activities from the carboxy-terminus of tubulin.
Similarity
Belongs to the peptidase M14 family.
Mass
110.77 kDa
Sequence
MCPALSTDLKQEVLTDPYESFMHHHLQYYGYFRGLEPREQFKLPVQRCRKVVTDSDSDMPSSQEDQKKLVYSLLLDSPVFKSRQLVFEDQEGKIIPRLREPKDLYGSSSQDGCWQQARWPSECEVIKQDISHIEWDPTDREIFYKPTGNEPKPPVVSEGTGAVVYEISPAHKGSYFKGSRTGGRKCSHRKNQKVQCNNDLQFESRFESGNLQKAMKVGMYEYELTLRTDLYTSKHTQWFYFQVKNTRKGVPYRFTITNLMKTNSLYNEGLKPLLYSQQDAALKGIGWRREGKDIKYYKNTRSLDGRSLYSLTWTFEFPHDDDICYFAHCYPYTYSDLQRDLKSKISDPACSHYCKLRTLCRSLAGNSIYLLTITSPSTNLTTGAKKKAIVVTARVHPGETNGSWMMKGFLDFILSDSPDAQLLRDTFIFKVVPMLNPDGVIVGNYRCSLSGRDLNRNYKSMLKDAFPCIWHTRSMVKRLLTEREVILYCDFHGHSRKNNVFMYGCNSKGHPLTKLHERIFPLMLSKNAPDKFLFKGCKFKVQKSKEGTGRIDMWKQGIQNSYTMEATFGGSTLGNRKDTHFTTQDLKSMGHHFCDTLLDYCDPDSSKFKLCLSELQRLVEEDIREKMKQLGRDMDSDFTLSDITLSDLESSTSGSNSSESDGLPAHLVDIAEKFYQKKKRRLRSRKERNSLYQKRNARQKQKLHEAVEVSEPAAHIVRNELTKSSGKRKKEQKVAKIKFQEDLVPQTEENLTTAAPTEKSSMLYSRKPESVSMKTQMINSLPTSCVRDFMDLDHVCERQMTIRPRPSANGNRLPLIITVVQQSTLPPVPKGISALKQHPPPFHSILDQSGDQLTVADHVFRRDKSVAKRGFSSAGIRPYCSGISGEKQKVLDGSIVPLDLHLSLSPEVHRQNKPRQEPLITLGSTEYFEGFLPKPKTDPVRRFPGISSSEPHFPNSSEDITVRNTMK
Protein
Cytosolic carboxypeptidase 2: agbl2

Gene
AGBL2
Protein
Cytosolic carboxypeptidase 2
Organism
Homo sapiens
Length
902 amino acids
Function
Metallocarboxypeptidase that mediates deglutamylation of target proteins. Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation in proteins such as tubulins. Also removes gene-encoded polyglutamates from the carboxy-terminus of target proteins such as MYLK. Does not show detyrosinase or deglycylase activities from the carboxy-terminus of tubulin.
Similarity
Belongs to the peptidase M14 family.
Mass
104.194 kDa
Sequence
MFPALETHLKQTIPDPYEDFMYRHLQYYGYFKAQRGSLPNSATHQHVRKNNPQCLLNGSLGEKDDLIPDTLQKEKLLWPISLSSAVHRQIEAINRDFHSCLGWMQWRGLSSLQPPPPRFKDSPASAFRVAGITDSHMLSLPHLRSRQLLYDELDEVNPRLREPQELFSILSTKRPLQAPRWPIECEVIKENIHHIEWAPPQPEYFYQPKGNEKVPEIVGEKKGTVVYQLDSVPIEGSYFTSSRVGGKRGIVKELAVTLQGPEDNTLLFESRFESGNLQKAVRVDTYEYELTLRTDLYTNKHTQWFYFRVQNTRKDATYRFTIVNLLKPKSLYTVGMKPLLYSQLDANTRNIGWRREGNEIKYYKNNTDDGQQPFYCLTWTIQFPYDQDTCFFAHFYPYTYTDLQCYLLSVANNPIQSQFCKLQTLCRSLAGNTVYLLTITNPSQTPQEAAAKKAVVLSARVHPGESNGSWVMKGFLDFILSNSPDAQLLRDIFVFKVLPMLNPDGVIVGNYRCSLAGRDLNRHYKTILKESFPCIWYTRNMIKRLLEEREVLLYCDFHGHSRKNNIFLYGCNNNNRKYWLHERVFPLMLCKNAPDKFSFHSCNFKVQKCKEGTGRVVMWRMGILNSYTMESTFGGSTLGNKRDTHFTIEDLKSLGYHVCDTLLDFCDPDQMKFTQCLAELKELLRQEIHKKFHELGQDVDLEGSWSDISLSDIESSTSGSDSSLSDGLPVHLANIADELTQKKKMFKKKKKKSLQTRKQRNEQYQKKNLMQKLKLTEDTSEKAGFASTLQKQPTFFKNSENSSFLPMKNENPRLNETNLNRRDKDTPLDPSMATLILPKNKGRMQNKKPGFTVSCSPKRTINSSQEPAPGMKPNWPRSRYPATKRGCAAMAAYPSLHIYTYP
Protein
Cytosolic carboxypeptidase 2: AGBL2

Gene
Agbl2
Protein
Cytosolic carboxypeptidase 2
Organism
Mus musculus
Length
862 amino acids
Function
Metallocarboxypeptidase that mediates deglutamylation of target proteins. Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation in proteins such as tubulins. Also removes gene-encoded polyglutamates from the carboxy-terminus of target proteins such as MYLK. Does not show detyrosinase or deglycylase activities from the carboxy-terminus of tubulin.
Similarity
Belongs to the peptidase M14 family.
Mass
99.216 kDa
Sequence
MNVLLEMAFLSQTLPDPYEDFIHHHLQYYGYFKAQKSSLPNSGTHQRVWRNSPRYMLNGSFGERDDFISDSLEKEMLLWPTCLSSTGHAHIDAVNRDSLLLSSPLLRTRQLIFDELDEASPRLREPRELFSCFSSRGPLQAPRWPIECEVIKENIHHIEWVPHQPEYFYQPTGSEKVPEIVGEEQGTVVYQLDSVPAEGTYFTSSRIGGKRGTIKELAVTLQGPDDNTLLFESRFESGNLQKAVRVGIYEYELTLRTDLYTDKHTQWFYFRVQNTRKDATYRFTIVNLLKPKSLYAVGMKPLMYSQLDATIYNIGWRREGREIKYYKNNVDDGQQPLYCLTWTTQFPHDQDTCFFAHFYPYTYTDLQCYLLSVANNPIQSQFCKLRALCRSLAGNTVYLLTITNPSRTPQEAAAKKAVVLSARVHPGESNSSWIMNGFLDFILSNSPDAQLLRDIFVFKVIPMLNPDGVIVGNYRCSLAGRDLNRHYKTVLKDSFPCIWYTKNMIKRLLEEREVLLYCDFHGHSRKNNIFLYGCHSNNRKHWLHERVFPLMLSKNAPDKFSFDSCNFKVQKCKEGTGRVVMWRMGIINSYTMESTFGGSTLGSKRDTHFTIEDLKSLGYHVCDTLLDFCDPDQTKYTQCLQELKELLQQEINKKLNNFGQDMDLEGNWSDIPLSDIESSTSGSDSSLSDGPPIRLLNIVADEPNQKTVLKNPKKKRLQTRKQRNEQYQKSYLMRELKLTENAPGRARFVSTLQKQPTFLKSPESPSPSVRRSENPRLNETQLSGREKGTSLDPPLTSPKNKERIQSKKPGFTASCSPKRSTNSSLGPAPDVKPNWSKTRYSATRKDHATMAVYPSLHIYTYP
Protein
Cytosolic carboxypeptidase 2: Agbl2

Gene
AGBL2
Protein
Cytosolic carboxypeptidase 2
Organism
Macaca fascicularis
Length
840 amino acids
Function
Metallocarboxypeptidase that mediates deglutamylation of target proteins. Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation in proteins such as tubulins. Also removes gene-encoded polyglutamates from the carboxy-terminus of target proteins such as MYLK. Does not show detyrosinase or deglycylase activities from the carboxy-terminus of tubulin.
Similarity
Belongs to the peptidase M14 family.
Mass
97.606 kDa
Sequence
MFPALETHLKQTIPDPYEDFMYRHLQYYGYFKAQRGSLPNSATHQHVRKNNPQYLLHGSLGGKDDLIPDTLQKEKLLWPTSLSSAVHRQIEAINRDSHMLSLPHLRSRQLLYDELDEVNPRLREPQELFSILSTKRPLLAPRWPIECEVIKESIHHIEWAPPQPEYFYQPKGNEKVPEIVGEKKGTVVYQLDSVPTEGSYFTSSRVGGKQGIIKELAVTLQGPEDNTLLFESRFECGNLQKAVRVDTYEYELTLRTDLYTNRHTQWFYFRVQNTRKDATYRFTIVNLLKPKSLYTVGMKPLLYSQMDANTRNIGWRREGNEIKYCKNNMDDGQQPFYCLTWTIQFPYDQDTCFFAHFYPYTYTDLQCYLLSVANNPIQSQFCKLQTLCRSLAGNTVYLLTITNPSQTPQEAAAKKAVVLSARVHPGESNGSWVMKGFLDFILSNSPDAQLLRDIFVFKVLPMLNPDGVIVGNYRCSLAGRDLNRHYKTILKESFPCIWYTRNMIKRLLEEREVLLYCDFHGHSRKNNTFLYGCNNNNRKYWLHERVFPLMLSKNAPDRFSFHSCNFKVQKCKEGTGRVVMWRMGILNSYTMESTFGGSTLGSKRDTHFTIEDLKSLGYHVCDTLLDFCDPDQTKFTQCLAELKELLRQEIHKKFHELGQDVDLEESWSDISLSDIESSTSGSDSSLSDGLPVHLANIADELTQKKMFKKKKKKSLQTRKQRNEQYQKKNLMWKLKLTEDTSEFASTLQKHPAFFKNSESSSFLPMRNENPRLNETNLNRRDKDTSLDPSMTTLILPKNKGRMQTNLNRRDKDTSLDPSMTTLILPKNKGRMQVLHLIYCI
Protein
Cytosolic carboxypeptidase 2: AGBL2