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AF_2237

Gene
AF_2237
Protein
dITP/XTP pyrophosphatase
Organism
Archaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126)
Length
181 amino acids
Function
Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides xanthosine triphosphate (XTP), deoxyinosine triphosphate (dITP) and ITP. Probably functions as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Shows very low activity on dGTP or dUTP, and has nearly no activity toward the canonical nucleotides ATP, CTP, and TTP.
Similarity
Belongs to the HAM1 NTPase family.
Mass
20.953 kDa
Sequence
MYFITSNEGKFREVREMASKYGIEIEWLKMEYIEPQGSSLEEIARLSAEMLAEKVEGEFVIEDSGLFVEALKGFPGPYSSYVFKTIGNEGILKLMEGVENRKAYFMAVVAYFDGKEVRTFTGKVEGEISREMRGTQGFGYDPIFLYGNKTFAEMATEEKNQVSHRRKAFEEFFRWLKENKI