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ADM

Gene
ADM
Protein
Protein ADMETOS
Organism
Arabidopsis thaliana
Length
264 amino acids
Function
Product of a dosage-sensitive gene that contributes to the maintenance of paternally and maternally imprinted gene expression in the endosperm in order to balance parental contributions. Underlies postzygotic reproductive isolation by promoting triploid seed arrest in a genetic dosage-dependent manner, thus being a component of postzygotic interploidy hybridization barriers.
Mass
29.902 kDa
Sequence
MFSGEGASQIRIAPEDKPIQWCYQILKSRDFKSARYITQMNLKLSKTRHDEYEKGLAICDILIAAENRLPNGLLDCYGMIRMTRPGLVLYQNIEKELNLLGWGNISNPFPFRQEASEKFFFAWSLLSNPTIKEMYDYATSDEVNLEPQGNVNEYMDVDSSSQSGYGLGSVLCSDLPGSEYLKEFADVYPLPLAEKGQAPHNRFGWYDHNVGPETNNNVVVTYEDAKEEECDMSSSSELRIINGRRVKITIEEAAETSDTPSCSR

Gene
ADM
Protein
ADM
Organism
Bos taurus
Length
188 amino acids
Function
Hypotensive peptide. May function as a hormone in circulation control (By similarity).
Similarity
Belongs to the adrenomedullin family.
Mass
20.963 kDa
Sequence
MKLVPVALLYLGSLAFLGVDTARLDVAAEFRKKWNKWALSRGKRELRESSSYPTGLADVKAGPVQTLIRPQDVKGASRSPQASSPDAARIRVKRYRQSLNNFQGLRSFGCRFGTCTVQKLAHQIYHFTDKDKDGSAPRSKISPQGYGRRRRRSLPEAGLGRTLLQPPEPKLRGAPDSRVHQVLATLRI
Protein

Gene
ADM
Protein
ADM
Organism
Canis lupus familiaris
Length
188 amino acids
Function
AM and PAMP are potent hypotensive and vasodilatator agents.
Similarity
Belongs to the adrenomedullin family.
Mass
20.929 kDa
Sequence
MKLVPVALLYLGSLAFLGADTARLDVASEFRKKWNKWAVSRGKRELRVSSSYPTGLAEVKAGPAQTLIRTQDVKGASRNPQTSGPDAARIRVKRYRQSMNNFQGPRSFGCRFGTCTVQKLAHQIYQFTDNDKDGVAPRSKISPQGYGRRRRRSLPEPGLRRTLLFPEPRPGGAPAPRAHQVLANLLKM
Protein

Gene
ADM
Protein
ADM
Organism
Sus scrofa
Length
188 amino acids
Function
AM and PAMP are potent hypotensive and vasodilatator agents.
Similarity
Belongs to the adrenomedullin family.
Mass
20.893 kDa
Sequence
MKLVPVALMYLGSLAFLGADTARLDVAAEFRKKWNKWALSRGKRELRLSSSYPTGIADLKAGPAQTVIRPQDVKGSSRSPQASIPDAARIRVKRYRQSMNNFQGLRSFGCRFGTCTVQKLAHQIYQFTDKDKDGVAPRSKISPQGYGRRRRRSLPEASLGRTLRSQEPQAHGAPASPAHQVLATLFRI
Protein

Gene
ADM
Protein
ADM
Organism
Homo sapiens
Length
185 amino acids
Function
AM and PAMP are potent hypotensive and vasodilatator agents. Numerous actions have been reported most related to the physiologic control of fluid and electrolyte homeostasis. In the kidney, am is diuretic and natriuretic, and both am and pamp inhibit aldosterone secretion by direct adrenal actions. In pituitary gland, both peptides at physiologically relevant doses inhibit basal ACTH secretion. Both peptides appear to act in brain and pituitary gland to facilitate the loss of plasma volume, actions which complement their hypotensive effects in blood vessels.
Similarity
Belongs to the adrenomedullin family.
Mass
20.42 kDa
Sequence
MKLVSVALMYLGSLAFLGADTARLDVASEFRKKWNKWALSRGKRELRMSSSYPTGLADVKAGPAQTLIRPQDMKGASRSPEDSSPDAARIRVKRYRQSMNNFQGLRSFGCRFGTCTVQKLAHQIYQFTDKDKDNVAPRSKISPQGYGRRRRRSLPEAGPGRTLVSSKPQAHGAPAPPSGSAPHFL
Protein

Gene
Adm
Protein
ADM
Organism
Rattus norvegicus
Length
185 amino acids
Function
AM and PAMP are potent hypotensive and vasodilatator agents.
Similarity
Belongs to the adrenomedullin family.
Mass
20.636 kDa
Sequence
MKLVSIALMLLGSLAVLGADTARLDTSSQFRKKWNKWALSRGKRELQASSSYPTGLVDEKTVPTQTLGLQDKQSTSSTPQASTQSTAHIRVKRYRQSMNQGSRSTGCRFGTCTMQKLAHQIYQFTDKDKDGMAPRNKISPQGYGRRRRRSLPEVLRARTVESSQEQTHSAPASPAHQDISRVSRL
Protein

Gene
Adm
Protein
ADM
Organism
Mus musculus
Length
184 amino acids
Function
AM and PAMP are potent hypotensive and vasodilatator agents.
Similarity
Belongs to the adrenomedullin family.
Mass
20.75 kDa
Sequence
MKLVSITLMLLGSLAFLGADTAGPDTPSQFRKKWNKWALSRGKRELQASSSYPTGLADETTVPTQTLDPFLDEQNTTGPLQASNQSEAHIRVKRYRQSMNQGSRSNGCRFGTCTFQKLAHQIYQLTDKDKDGMAPRNKISPQGYGRRRRRSLLEVLRSRTVESSQEQTHTAPGPWAHISRLFRI
Protein