Protein
Lipoyl synthase, mitochondrial
Organism
Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Function
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
Similarity
Belongs to the radical SAM superfamily. Lipoyl synthase family.
Sequence
MAASTSHLRSLCSSTRSLSRSGVIVTPIACRGYATTDPSPSATTPTPVRRRTTFKDKLNAGPSFSDFVSNGNDNAPLDPSEAYALKTALVGPAGRKKEMTRLPSWLKTPIPDSKNYQRLKKDLRGLNLHTVCEEARCPNISDCWGGSDKSSATATIMLMGDTCTRGCRFCSVKTSRAPPPLDPHEPENTAEAISRWGLGYVVLTSVDRDDLVDGGARHFAETVIKIKQKAPSILVECLTGDYAGDLDMVKLVARSGLDVYAHNVETVEALTPQVRDRRANFQQSLRVLDAAKKAQPTLITKTSLMLGLGETDEQLWDALRQLRAVNVDVVTFGQYMRPTKRHMAVHEYVTPDRFELWRQRALEMGFLYCASGPLVRSSYKAGEAFIENVLKKRRAASGGAETIGERPVAVDEASR