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AATF

Gene
AATF
Protein
Protein AATF
Organism
Gallus gallus
Length
574 amino acids
Function
May function as a general inhibitor of the histone deacetylase HDAC1.
Similarity
Belongs to the AATF family.
Mass
65.047 kDa
Sequence
MAAPLAQQLEELLNPRPDLRDPEDDAEEATVAKVIDRFEDETADDVLPVGNIRKKASVSLLEADQRYSGKATSRKALQEELWGDALSEEGSAEEALDEWYSGSEDSEDNGSSGSKTEEQPSSAGSDQEDNLEDDEERDSSAKAPKFSFQNITDFEKFAEGMDDVGSSDGEDEDDASMEEGSDDEKYEGENHDHVKDTNDNEDDGGVMTFSKGQTSDEVEKGKAVKNQLALWDQILEGRIKMQKALVIVNRLPQPDTFPLFRKEGGQEFDSAVESCCKAVDTLLRVLVDIQDELLYQCPGTRHLVDGKQSKPESDDEIPSSSDEERAGEAQEKRKRPPKRKLKAEDIPEFIAKRYSDYRTYRNHILQKWHEKTKLASGKMAKGFGAFERSILTQIDHILMDKERLLRRTQTKRSVYRVLGKEEQDSHPVPEHLPENSEVLPQADSNRHLKDIDEEIFDDDDFYHQLLRELIERKTTSLDPNDQVAMGRQWLAIQKLRSKIKKKVDRKASKGRKIRYHVHSKLVSFMAPIDHCTMNDDARTELYRSLFGRMMQSEGPERGWHPGPPAPAGSAPYTL

Gene
AATF
Protein
Protein AATF
Organism
Homo sapiens
Length
560 amino acids
Function
May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. Also antagonizes PAWR mediated induction of aberrant amyloid peptide production in Alzheimer disease (presenile and senile dementia), although the molecular basis for this phenomenon has not been described to date.
Similarity
Belongs to the AATF family.
Mass
63.133 kDa
Sequence
MAGPQPLALQLEQLLNPRPSEADPEADPEEATAARVIDRFDEGEDGEGDFLVVGSIRKLASASLLDTDKRYCGKTTSRKAWNEDHWEQTLPGSSDEEISDEEGSGDEDSEGLGLEEYDEDDLGAAEEQECGDHRESKKSRSHSAKTPGFSVQSISDFEKFTKGMDDLGSSEEEEDEESGMEEGDDAEDSQGESEEDRAGDRNSEDDGVVMTFSSVKVSEEVEKGRAVKNQIALWDQLLEGRIKLQKALLTTNQLPQPDVFPLFKDKGGPEFSSALKNSHKALKALLRSLVGLQEELLFQYPDTRYLVDGTKPNAGSEEISSEDDELVEEKKQQRRRVPAKRKLEMEDYPSFMAKRFADFTVYRNRTLQKWHDKTKLASGKLGKGFGAFERSILTQIDHILMDKERLLRRTQTKRSVYRVLGKPEPAAQPVPESLPGEPEILPQAPANAHLKDLDEEIFDDDDFYHQLLRELIERKTSSLDPNDQVAMGRQWLAIQKLRSKIHKKVDRKASKGRKLRFHVLSKLLSFMAPIDHTTMNDDARTELYRSLFGQLHPPDEGHGD

Gene
Aatf
Protein
Protein AATF
Organism
Mus musculus
Length
526 amino acids
Function
May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression (By similarity).
Similarity
Belongs to the AATF family.
Mass
59.482 kDa
Sequence
MAAPQPLALQLEQLLNPRPREADPEADPEEATRARVIDRFDEGEEEKDDLAVSSIRKLAPVSLLDTDKRYSGKTTSRKAWKEDHWEQALPSSSDNEASDEGGSEDGDSEGLGLEEISEDVDEDLEDNKISDEGGSEDGDSEGLGLEEFSEDVEEDLEGEDEEDREEDRNSEDDGVVAAFSSVKVSEEVEKGRAVKNQIALWDQLLEGRIKLQKALLTTNQLPQPDVFPVFKDKGGPEFASALKNSHKALKALLRSLVDLQEELLFQYPDTRHIVNGAKPNTESEEISSEDDELVGEKKKQRKAPPKRKLEMEDYPSFMAKRFADFTIYRNHTLQKWHDKTKLASGKLGKGFGAFERSILTQIDHIMMDKERLLRRTQTKRSAYRVLGKPEPVPEPVAETLPGEPETLPQGPANAHLRDLDEEIFDDDDFYHQLLRELIERKTSSLDPNDQVAMGRQWLAIQKLRSKIRKKVDRKASKGRKLRFHVLSKLLSFMAPIDHTAMSDDARTELFRSLFGQLNPPDADRGK

Gene
Aatf
Protein
Protein AATF
Organism
Rattus norvegicus
Length
523 amino acids
Function
May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. May negatively regulate the pro-apoptotic activity of DAPK3/ZIPK. Can act cooperatively with TSG101 to stimulate AR mediated transcription activation (By similarity). May negatively regulate the pro-apoptotic activity of DAPK3/ZIPK. Can act cooperatively with TSG101 to stimulate AR mediated transcription activation.
Similarity
Belongs to the AATF family.
Mass
59.497 kDa
Sequence
MAELQPLALQLEQLLNPRPREADPEADPEEATRARVIDRFDEGEEEEDDLPVSSIRKLAPVSLLDTDKRYSGKTTSRKAWKEDHWDQTLPSSSDNEIPDEGGSEAGDSEGLEELSEDVEEDLEDNEIPDEGGSEDGDSEGLEEEISEDVEEDLEGEDEEDREEDRNSEDDGVVMAFSGVKVSEEVEKGRAVKNQIALWDQLLEGRIKLQKALLTTNQLPQPDVFPVFKDKGGPEFASALKNSHKALKALLRSLVDLQEELLFQYPDTRYLVKGTKPNAESEEISSEDDELVGEKKKQRKAPPKRKLEMEDYPSFMAKRSADFTVYRNRTLQKWHDKTKLASGKLGKGFGAFERSILTQIDHILMDKERLLRRTQTKRSAYRVLGKPEPVPEPVAETLPGEPESLPQVPANAHLKDLDEEIFDDDDFYHQLLRELIERKTSSLDPNDQVAMGRQWLAIQKLRSKIRKKVDRKASKGRKLRFHVLSKLLSFMAPIDHTAMNDEARTELYRSLFGQLNRLDADHGQ

Gene
Aatf
Protein
Protein Aatf
Organism
Drosophila melanogaster
Length
488 amino acids
Function
May function as a general inhibitor of the histone deacetylase HDAC1.
Similarity
Belongs to the AATF family.
Mass
55.953 kDa
Sequence
MLRKSKKQPQTVAEKVSKLLAHPNESDSAEDSDFDVATGPRLVDFEEEEYDLPDARSTDFRKRNVKLLSEQSDRYKGKISSRKELDDDEDKDDEQEVSYEESDEDDENLTNFKQKLNAGGAEDSEEETAAGHSESGEESEEIESNLTDFKKKFEAGDFKYDDDEEEDDDSEEEDHSQESEGDDDDSEDDEAEDDAIKPSDVMSKTNHQAEIQKGLAVQNQLRIWERLLELRINTQKFTSKANQLPAPETLTKLASESDELQSVLNEAQERSSKLLQQLLSLQSALHQQYSEMKKSVKRKQPTEDSGPAVKKFGSVLQSNFQQMIGYRNEVLLKWDDRTKLLTPGAGVKRKSLQEDYDIIKKIGSALANREALVEKSQTPKNSQAEQQENTPVQRLKHIYDDSDFYHQQLRELIEYKASTSSNMSEITKQFVELQKLRQKMKKKVDTRASKGRKLRYVVHNKLINFMAPNESSDWTDASKSELYKSLFV