Protein
Tryptophan 2,3-dioxygenase
Function
Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L-tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety.
Similarity
Belongs to the tryptophan 2,3-dioxygenase family.
Sequence
MSCPVGNHNGDPQGGQRLGSEAGMLYGEYLMLDKVLSAQRMLSVESNKPVHDEHLFIVTHQAYELWFKQIIFELDSIRSLFSTEHMEESRTLEILKRLNRIVMILKLLVDQVPILETMTPLDFMDFRDFLSPASGFQSLQFRLLENKLGVKTEHRVKYNQKYSEVFASDPCAIERLSITESEPSLADLVQKWLERTPGLETNGFNFWGKFEESVEQLLADQEASAMEEEHENVKNYRLMDIEKRREVYKSIFDASVHDALVARGDRRFTHRALQGAIMITFYRDEPRFSQPHQLLMLLMDIDSLITKWRYNHVIMVQRMIGSQQLGTGGSSGYQYLRSTLSDRYKVFIDLFNLSTFLIPRGSIPPLTCEMQKALNLAWGSPVHQAKQINYAAK