Protein
DNA base-flipping protein
Organism
Vibrio parahaemolyticus serotype O3:K6 (strain AQ3810)
Function
Involved in DNA damage recognition. Binds DNA containing O(6)-methylguanine (PubMed:20212037). Binds to the damaged base and flips the base out of the DNA duplex into an extrahelical conformation, which allows processing by repair proteins (By similarity).
Similarity
Belongs to the MGMT family. ATL subfamily.
Sequence
MDQFLVQIFAVIHQIPKGKVSTYGEIAKMAGYPGYARHVGKALGNLPEGSKLPWFRVINSQGKISLKGRDLDRQKQKLEAEGIEVSEIGKIALRKYKWQP