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7OMT

Gene
7OMT
Protein
(R,S)-reticuline 7-O-methyltransferase
Organism
Papaver somniferum
Length
355 amino acids
Function
Catalyzes the transfer of a methyl group to reticuline to form laudanine. Methylates the simple catechols guaiacol and isovanillic acid as well as the tetrahydrobenzylisoquinolines (R)-reticuline, (S)-reticuline, (R,S)-orientaline, (R)-protosinomenine and (R,S)-isoorientaline. Involved in the production of laudanine.
Similarity
Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family.
Mass
39.842 kDa
Sequence
MDTAEERLKGQAEIWEHMFAFVDSMALKCAVELGIPDIINSHGRPVTISEIVDSLKTNTPSSSPNIDYLTRIMRLLVHKRLFTSELHQESNQLLYNLTRSSKWLLKDSKFNLSPLVLWETNPILLKPWQYLGKCAQEKSSPFERAHGCEIWDLALADPKFNNFLNGAMQCSTTTIINEMLLEYKDGFSGIAGSLVDVGGGTGSIIAEIVKAHPHIQGINFDLPHVVATAAEFPGVKHVGGDMFVDIPEADAVIMKWILHDWSDEDCTIILKNCYRAIRKKKNGKVIIVDCVLRPDGNDLFDKMGLIFDVLMMAHTTAGKERTEAEWKILLNNAGFPRYNVIRTPAFPCIIEAFPE