7DLH

Gene

7DLH

Protein

7-deoxyloganic acid hydroxylase

Organism

Catharanthus roseus

Length

521 amino acids

Function

Component of the seco-iridoid and derivatives monoterpenoid indole alkaloids (MIAs, e.g. vincristine, quinine, and strychnine) biosynthesis pathway. Catalyzes the conversion of 7-deoxyloganic acid into loganic acid (PubMed:24710322, PubMed:24103035). Not active on 7-deoxyloganetic acid (PubMed:24710322).

Similarity

Belongs to the cytochrome P450 family.

Mass

60.022 kDa

Sequence

MELNFKSIIFLVFVSLTLYWVYRILDWVWFKPKKLEKCLREQGFKGNPYRLFLGDQYDSGKLIRQALTKPIGVEEDVKKRIVPHILKTVGTHGKKSFMWVGRIPRVNITDPELIKEVLTKYYKFQKNHHDLDPITKLLLTGIGSLEGDPWAKRRKIINAAFHFEKLKLMLPAFYLSCRDMVTKWDNKVPEGGSAEVDVWHDIETLTGDVISRTLFGSNFEEGRRIFELMKELTALTIDVIRSVYIPGQRFLPTKRNNRMRAIDKEVRVRITEIINKKMKVMKSGEAASAADDFLGILLECNLNEIKEQGNNKSAGMTIGEIIGECKLFYFAGQDTTSTLLVWTMVLLSRFPEWQTRAREEVFQVFGNKTPDYDGISHLKVITMILYEVLRLYTPVAELTKVAHEATQLGKYFIPAGVQLMMPQILLHHDPEIWGEDVMEFKPERFAEGVLKATKSQGSFFPFSLGPRMCIGQNFALLEAKMAMSLILRRFSFELSPSYVHAPFTLITMQPQYGAHLILHKL

Protein

7-deoxyloganic acid hydroxylase: 7DLH