Protein
Probable deoxyuridine 5'-triphosphate nucleotidohydrolase
Organism
Sulfolobus islandicus rod-shaped virus 1
Function
This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. It does probably not deaminate dCTP.
Similarity
Belongs to the dUTPase family.
Sequence
MILSDRDIKTYINSKKLVINPLSEDTIRENGVDLKIGNEIVRIKENMEKEVGDEFIIYPNEHVLLTTKEYIKLSNDIIAFCNLRSTFARKGLLIPPTIVDAGFEGQLTIELVGSSIPVKLKSGERFLHLIFARTLTPVEKPYNGKYQKQKGVTLAKED